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573097 STAT3 Inhibitor III, WP1066

STAT3 Inhibitor III, WP1066, CAS 857064-38-1, is a cell-permeable AG490 tyrphostin analog that acts as a STAT3 pathway inhibitor. A potent anti-tumor agent.

STAT3 Inhibitor III, WP1066 MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Primary Target: STAT3 pathway
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573097
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Overview

Replacement Information

Key Specifications Table

CAS #Empirical Formula
857064-38-1C₁₇H₁₄BrN₃O

Pricing & Availability

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573097-10MG
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      Description
      OverviewA cell-permeable AG 490 (Cat. No. 658401) tyrphostin analog that acts as an effective STAT3 pathway inhibitor and a much more potent antitumor agent than AG 490 in inhibiting malignant glioma growth both in cultures in vitro (IC50 = 5.6 and 3.7 µM in a viability assay using U87-MG and U373-MG, respectively; no inhibition against nontumor NHA at 10 µM) and in mice in vivo. Shown to cross blood-brain barrier in mice in vivo. Also available in InSolution™ format (Cat. No. 573129.
      Catalogue Number573097
      Brand Family Calbiochem®
      References
      ReferencesIwamaru, A., et al. 2007. Oncogene, 26, 2435.
      Product Information
      CAS number857064-38-1
      ATP CompetitiveN
      FormOff-white solid
      Hill FormulaC₁₇H₁₄BrN₃O
      Chemical formulaC₁₇H₁₄BrN₃O
      ReversibleN
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetSTAT3 pathway
      Primary Target IC<sub>50</sub>5.6 and 3.7 µM in inhibiting malignant glioma growth in a viability assay using U87-MG and U373-MG, respectively
      Purity≥97% by HPLC
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Irritant
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalog Number GTIN
      573097-10MG 04055977266382

      Documentation

      STAT3 Inhibitor III, WP1066 SDS

      Title

      Safety Data Sheet (SDS) 

      STAT3 Inhibitor III, WP1066 Certificates of Analysis

      TitleLot Number
      573097

      References

      Reference overview
      Iwamaru, A., et al. 2007. Oncogene, 26, 2435.

      Brochure

      Title
      Pathways and Biomarkers of JAK/STAT Signaling
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision15-January-2009 RFH
      DescriptionA cell-permeable AG 490 (Cat. No. 658401) tyrphostin analog that acts as an effective STAT3 pathway inhibitor and a much more potent antitumor agent than AG 490 in inhibiting malignant glioma growth both in cultures in vitro (IC50 = 5.6 and 3.7 µM in a viability assay using U87-MG and U373-MG, respectively; no inhibition against nontumor NHA at 10 µM) and in mice in vivo. Shown to cross blood-brain barrier in mice in vivo.
      FormOff-white solid
      Intert gas (Yes/No) Packaged under inert gas
      CAS number857064-38-1
      Chemical formulaC₁₇H₁₄BrN₃O
      Structure formulaStructure formula
      Purity≥97% by HPLC
      SolubilityDMSO (10 mg/ml) or Ethanol (5 mg/ml)
      Storage Protect from light
      +2°C to +8°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Toxicity Irritant
      ReferencesIwamaru, A., et al. 2007. Oncogene, 26, 2435.