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573131 STAT3 Inhibitor XIV, LLL12 - Calbiochem

The STAT3 Inhibitor XIV, LLL12 controls the biological activity of STAT3. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

STAT3 Inhibitor XIV, LLL12 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: 5-Hydroxy-9,10-dioxo-9,10-dihydroanthracene-1-sulfonamide

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      Overview

      Replacement Information

      Key Specifications Table

      Empirical Formula
      C₁₄H₉NO₅S
      Description
      OverviewA cell-permeable hydroxyanthraquinone compound that binds directly to the phosphoryl Tyr705 binding site of the STAT3 monomer and acts as selective and reversible inhibitor of STAT3 signaling. Shown to block STAT3 phosphorylation and its subsequent nuclear localization and DNA binding, but has no effect on IL-4, interferon-α and interferon-γ-induced STAT1, 2, 4, 6 and pJAK2, PI3-Kinase, or ERK signaling. Does not affect the activity of over 21 other closely related protein kinases (IC50 > 50 µM). Also shown to induce apoptosis in U266 and ARH-77 multiple myeloma cell lines (IC50 = 490 nM and 1.96 µM, respectively), and suppress hepatocellular carcinoma tumor growth in xenograft mouse model (5 mg/kg, i.v).
      Catalogue Number573131
      Brand Family Calbiochem®
      Synonyms5-Hydroxy-9,10-dioxo-9,10-dihydroanthracene-1-sulfonamide
      References
      ReferencesLin, L., et al. 2011. Cancer Res. 71, 7226.
      Lin, L., et al. 2011. Int. J. Cancer in press.
      Ball, S., et al. PLoS One 6, e18820.
      Liu, Y., et al. 2010. J. Biol. Chem. 285, 27429.
      Lin, L., et al. 2010. Neoplasia 12, 39.
      Product Information
      FormOrange powder
      Hill FormulaC₁₄H₉NO₅S
      Chemical formulaC₁₄H₉NO₅S
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Purity≥98% by HPLC
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalog Number GTIN
      573131 0

      Documentation

      STAT3 Inhibitor XIV, LLL12 - Calbiochem Certificates of Analysis

      TitleLot Number
      573131

      References

      Reference overview
      Lin, L., et al. 2011. Cancer Res. 71, 7226.
      Lin, L., et al. 2011. Int. J. Cancer in press.
      Ball, S., et al. PLoS One 6, e18820.
      Liu, Y., et al. 2010. J. Biol. Chem. 285, 27429.
      Lin, L., et al. 2010. Neoplasia 12, 39.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision27-July-2012 JSW
      Synonyms5-Hydroxy-9,10-dioxo-9,10-dihydroanthracene-1-sulfonamide
      DescriptionA cell-permeable hydroxyanthraquinone compound that binds directly to the phosphoryl Tyr705 binding site of the STAT3 monomer and acts as selective and reversible inhibitor of STAT3 signaling. Shown to block STAT3 phosphorylation and its subsequent nuclear localization and DNA binding, but has no effect on IL-4, interferon-α and interferon-γ-induced STAT1, 2, 4, 6 and pJAK2, PI3-Kinase, or ERK signaling. Does not affect the activity of over 21 other closely related protein kinases (IC50 > 50 µM). Also shown to induce apoptosis in U266 and ARH-77 multiple myeloma cell lines (IC50 = 490 nM and 1.96 µM, respectively), and suppress hepatocellular carcinoma tumor growth in xenograft mouse model (5 mg/kg, i.v).
      FormOrange powder
      Intert gas (Yes/No) Packaged under inert gas
      Chemical formulaC₁₄H₉NO₅S
      Structure formulaStructure formula
      Purity≥98% by HPLC
      SolubilityDMSO (10 mg/ml)
      Storage Protect from light
      +2°C to +8°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Toxicity Standard Handling
      ReferencesLin, L., et al. 2011. Cancer Res. 71, 7226.
      Lin, L., et al. 2011. Int. J. Cancer in press.
      Ball, S., et al. PLoS One 6, e18820.
      Liu, Y., et al. 2010. J. Biol. Chem. 285, 27429.
      Lin, L., et al. 2010. Neoplasia 12, 39.