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572201 Streptozotocin - CAS 18883-66-4 - Calbiochem

An N-nitroso-containing diabetogenic compound that acts as a nitric oxide donor in pancreatic islets. An antibiotic effective against Gram-negative bacteria. Causes DNA alkylation and DNA strand breaks in pancreatic islet cells.

Streptozotocin - CAS 18883-66-4 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: 2-Deoxy-2-(3-methyl-3-nitrosoureido)-D-glucopyranose

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      Overview

      Replacement Information

      Key Specifications Table

      CAS #Empirical Formula
      18883-66-4C₈H₁₅N₃O₇
      Description
      OverviewAn N-nitroso-containing diabetogenic compound that acts as a nitric oxide donor in pancreatic islets. An antibiotic effective against Gram-negative bacteria. Causes DNA alkylation and DNA strand breaks in pancreatic islet cells.
      Catalogue Number572201
      Brand Family Calbiochem®
      Synonyms2-Deoxy-2-(3-methyl-3-nitrosoureido)-D-glucopyranose
      References
      ReferencesKroncke, K.D., et al. 1995. Biol. Chem. Hoppe Seyler 376, 179.
      Kwon, N.S., et al. 1994. FASEB J. 8, 529.
      Rasschaert, J., et al. 1992. Endocrinology 130, 3522.
      Bennett, R.A. and Pegg, A.E. 1981. Cancer Res. 41, 2786.
      Yamamoto, H., et al. 1981. Nature 294, 284.
      Product Information
      CAS number18883-66-4
      FormOff-white to pale yellow crystalline solid
      Hill FormulaC₈H₁₅N₃O₇
      Chemical formulaC₈H₁₅N₃O₇
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Purity≥95% by HPLC
      Physicochemical Information
      ContaminantsHeavy metals: ≤5 ppm
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      RTECSLZ5775000
      Safety Information
      R PhraseR: 20/21/22-45-46-61

      Harmful by inhalation, in contact with skin and if swallowed.
      May cause cancer.
      May cause heritable genetic damage.
      May cause harm to the unborn child.
      S PhraseS: 22-36/37/39-45

      Do not breathe dust.
      Wear suitable protective clothing, gloves and eye/face protection.
      In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Harmful & Carcinogenic / Teratogenic
      Storage -20°C
      Do not freeze Ok to freeze
      Special InstructionsUnstable in solution; reconstitute just prior to use. Following initial thaw, aliquot and freeze (-20°C).
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalog Number GTIN
      572201 0

      Documentation

      Streptozotocin - CAS 18883-66-4 - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      Streptozotocin - CAS 18883-66-4 - Calbiochem Certificates of Analysis

      TitleLot Number
      572201

      References

      Reference overview
      Kroncke, K.D., et al. 1995. Biol. Chem. Hoppe Seyler 376, 179.
      Kwon, N.S., et al. 1994. FASEB J. 8, 529.
      Rasschaert, J., et al. 1992. Endocrinology 130, 3522.
      Bennett, R.A. and Pegg, A.E. 1981. Cancer Res. 41, 2786.
      Yamamoto, H., et al. 1981. Nature 294, 284.

      Brochure

      Title
      Antibiotics Profiler
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision24-September-2010 JSW
      Synonyms2-Deoxy-2-(3-methyl-3-nitrosoureido)-D-glucopyranose
      DescriptionAn N-nitroso-containing compound that acts as a nitric oxide donor in pancreatic islets. An antibiotic effective against gram-negative bacteria. Causes DNA alkylation and DNA strand breaks in pancreatic islet cells. A diabetogenic agent.
      FormOff-white to pale yellow crystalline solid
      CAS number18883-66-4
      RTECSLZ5775000
      Chemical formulaC₈H₁₅N₃O₇
      Structure formulaStructure formula
      Purity≥95% by HPLC
      ContaminantsHeavy metals: ≤5 ppm
      SolubilityH₂O
      Storage -20°C
      Do Not Freeze Ok to freeze
      Special InstructionsUnstable in solution; reconstitute just prior to use. Following initial thaw, aliquot and freeze (-20°C).
      Toxicity Harmful & Carcinogenic / Teratogenic
      Merck USA index14, 8832
      ReferencesKroncke, K.D., et al. 1995. Biol. Chem. Hoppe Seyler 376, 179.
      Kwon, N.S., et al. 1994. FASEB J. 8, 529.
      Rasschaert, J., et al. 1992. Endocrinology 130, 3522.
      Bennett, R.A. and Pegg, A.E. 1981. Cancer Res. 41, 2786.
      Yamamoto, H., et al. 1981. Nature 294, 284.