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504596 TCN-201 - CAS 852918-02-6 - Calbiochem

TCN-201 - CAS 852918-02-6 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: 3-Chloro-4-fluoro-N-[(4-{[2-(phenylcarbonyl)hydrazino]carbonyl}phenyl)methyl]benzenesulfonamide, NMDA Antagonist X

Primary Target: NMDA receptors
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      Overview

      Replacement Information

      Key Specifications Table

      CAS #Empirical Formula
      852918-02-6C₂₁H₁₇ClFN₃O₄S
      Description
      Overview

      This product has been discontinued.



      A negative allosteric modulator selective for NR2A containing NMDA receptors (pIC50 = 6.8 and <4.3 µM for NR2A and NR2B, respectively). No effect on NR2B-containing NMDA receptors with concentrations less than 50 mM. Inhibition on NR2A containing NMDA receptors is glycine (or D-serine)-binding, but not glutamate-binding, dependent.
      Catalogue Number504596
      Brand Family Calbiochem®
      Synonyms3-Chloro-4-fluoro-N-[(4-{[2-(phenylcarbonyl)hydrazino]carbonyl}phenyl)methyl]benzenesulfonamide, NMDA Antagonist X
      References
      ReferencesBettini. E., et al. 2010. J. Pharm. Exp. Ther. 335, 644.
      Shin, A., et al. 2011. Br. J. Pharmacol. 166, 1002.
      Edman, S., et al. 2012. Neuropharmacology 63, 441.
      Hansen, K., et al. 2012. J. Neurosci. 32, 6197.
      Product Information
      CAS number852918-02-6
      FormWhite powder
      Hill FormulaC₂₁H₁₇ClFN₃O₄S
      Chemical formulaC₂₁H₁₇ClFN₃O₄S
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetNMDA receptors
      Purity≥98% by HPLC
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalog Number GTIN
      504596 0

      Documentation

      TCN-201 - CAS 852918-02-6 - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      References

      Reference overview
      Bettini. E., et al. 2010. J. Pharm. Exp. Ther. 335, 644.
      Shin, A., et al. 2011. Br. J. Pharmacol. 166, 1002.
      Edman, S., et al. 2012. Neuropharmacology 63, 441.
      Hansen, K., et al. 2012. J. Neurosci. 32, 6197.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision28-June-2013 JSW
      Synonyms3-Chloro-4-fluoro-N-[(4-{[2-(phenylcarbonyl)hydrazino]carbonyl}phenyl)methyl]benzenesulfonamide, NMDA Antagonist X
      DescriptionA negative allosteric modulator selective for NR2A containing NMDA receptors (pIC50 = 6.8 and <4.3 µM for NR2A and NR2B, respectively). No effect on NR2B-containing NMDA receptors with concentrations less than 50 mM. Inhibition on NR2A containing NMDA receptors is glycine (or D-serine)-binding, but not glutamate-binding, dependent.
      FormWhite powder
      CAS number852918-02-6
      Chemical formulaC₂₁H₁₇ClFN₃O₄S
      Structure formulaStructure formula
      Purity≥98% by HPLC
      SolubilityDMSO (5 mg/ml)
      Storage Protect from light
      +2°C to +8°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Standard Handling
      ReferencesBettini. E., et al. 2010. J. Pharm. Exp. Ther. 335, 644.
      Shin, A., et al. 2011. Br. J. Pharmacol. 166, 1002.
      Edman, S., et al. 2012. Neuropharmacology 63, 441.
      Hansen, K., et al. 2012. J. Neurosci. 32, 6197.