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616453 TGF-β RI Kinase Inhibitor III - CAS 356559-13-2 - Calbiochem

The TGF-β RI Kinase Inhibitor III, also referenced under CAS 356559-13-2, controls the biological activity of TGF-β RI Kinase. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: Transforming Growth Factor-β Type I Receptor Kinase Inhibitor III, 2-(5-Benzo[1,3]dioxol-4-yl-2-tert-butyl-1H-imidazol-4-yl)-6-methylpyridine, HCl, ALK5 Inhibitor III, SB-505124, HCl

Primary Target: Activin receptor-like kinase 4, 5, 7
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616453
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Overview

Replacement Information

Key Specifications Table

CAS #Empirical Formula
356559-13-2C₂₀H₂₁N₃O₂ • HCl

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      Description
      OverviewA cell-permeable imidazolyl-pyridine compound that acts as a potent, ATP-competitive, reversible, and selective inhibitor of activin receptor-like kinase 4 (IC50 = 129 nM), 5 ( IC50 = 47 nM), and 7. It inhibits p38 MAPKα only at much higher concentrations (IC50 = 10.6 µM) and has little effect against ALK1/2/3/6 as well as a panel of 26 other kinases.
      Catalogue Number616453
      Brand Family Calbiochem®
      SynonymsTransforming Growth Factor-β Type I Receptor Kinase Inhibitor III, 2-(5-Benzo[1,3]dioxol-4-yl-2-tert-butyl-1H-imidazol-4-yl)-6-methylpyridine, HCl, ALK5 Inhibitor III, SB-505124, HCl
      References
      ReferencesHu, T., et al. 2005. Am. J. Physiol. Renal Physiol. 289, F816.
      DaCosta Byfield, S., et al. 2004. Mol. Pharmacol. 65, 744.
      Product Information
      CAS number356559-13-2
      ATP CompetitiveY
      FormLight yellow solid
      Hill FormulaC₂₀H₂₁N₃O₂ • HCl
      Chemical formulaC₂₀H₂₁N₃O₂ • HCl
      Hygroscopic Hygroscopic
      ReversibleY
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetActivin receptor-like kinase 4, 5, 7
      Primary Target IC<sub>50</sub>129 nM, 47 nM, against activin receptor-like kinase 4, 5, respectively
      Purity≥97% by HPLC
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Irritant
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Hygroscopic Hygroscopic
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalog Number GTIN
      616453-2MG 04055977185843

      Documentation

      TGF-β RI Kinase Inhibitor III - CAS 356559-13-2 - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      TGF-β RI Kinase Inhibitor III - CAS 356559-13-2 - Calbiochem Certificates of Analysis

      TitleLot Number
      616453

      References

      Reference overview
      Hu, T., et al. 2005. Am. J. Physiol. Renal Physiol. 289, F816.
      DaCosta Byfield, S., et al. 2004. Mol. Pharmacol. 65, 744.

      Brochure

      Title
      TGF-b Signaling: Dual Role in Tumor Suppression and Oncogenesis

      Technical Info

      Title
      TGF-β Signaling: Dual Role in Tumor Suppression and Oncogenesis
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision13-September-2008 RFH
      SynonymsTransforming Growth Factor-β Type I Receptor Kinase Inhibitor III, 2-(5-Benzo[1,3]dioxol-4-yl-2-tert-butyl-1H-imidazol-4-yl)-6-methylpyridine, HCl, ALK5 Inhibitor III, SB-505124, HCl
      DescriptionA cell-permeable imidazolyl-pyridine compound that acts as a potent, ATP-competitive, reversible, and selective inhibitor of activin receptor-like kinase 4 (IC50 = 129 nM), 5 ( IC50 = 47 nM), and 7. It inhibits p38 MAPKα only at much higher concentrations (IC50 = 10.6 µM) and has little effect against ALK1/2/3/6 as well as a panel of 26 other kinases.
      FormLight yellow solid
      Intert gas (Yes/No) Packaged under inert gas
      CAS number356559-13-2
      Chemical formulaC₂₀H₂₁N₃O₂ • HCl
      Structure formulaStructure formula
      Purity≥97% by HPLC
      SolubilityDMSO (20 mg/ml) or H₂O (3 mg/ml)
      Storage Protect from light
      +2°C to +8°C
      Hygroscopic
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Toxicity Irritant
      ReferencesHu, T., et al. 2005. Am. J. Physiol. Renal Physiol. 289, F816.
      DaCosta Byfield, S., et al. 2004. Mol. Pharmacol. 65, 744.