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613225 TJU103

A non-peptidic organic compound that specifically blocks stable CD4-MHC class II binding.

TJU103 MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: N-(3-Indolylmethylene)-isonicotinic Hydrazone

Primary Target: Blocks stable CD4-MHC class II binding
613225
  
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      Overview

      Replacement Information

      Key Specifications Table

      CAS #Empirical Formula
      10245-44-0C₁₅H₁₂N₄O
      Description
      Overview

      This product has been discontinued.





      A non-peptidic organic compound that specifically blocks stable CD4-MHC class II binding. Exhibits significant inhibition of immune responses in animal models of autoimmune disease and allograft transplant rejection, suggesting its potential as a novel immunosuppressant. Does not exhibit any toxic effects in vivo, with normal lymphocyte cellularity and subset composition in the spleen and lymph nodes of mice 24 h after injection.
      Catalogue Number613225
      Brand Family Calbiochem®
      SynonymsN-(3-Indolylmethylene)-isonicotinic Hydrazone
      References
      ReferencesLi, S., et al. 1997. Proc. Natl. Acad. Sci. USA 94, 73.
      Product Information
      CAS number10245-44-0
      ATP CompetitiveN
      FormPale yellow solid
      Hill FormulaC₁₅H₁₂N₄O
      Chemical formulaC₁₅H₁₂N₄O
      ReversibleN
      Structure formula ImageStructure formula Image
      Applications
      Biological Information
      Primary TargetBlocks stable CD4-MHC class II binding
      Purity≥98% by HPLC (sum of two isomers)
      Physicochemical Information
      Cell permeableN
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage -20°C
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C).
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalog Number GTIN
      613225 0

      Documentation

      TJU103 Certificates of Analysis

      TitleLot Number
      613225

      References

      Reference overview
      Li, S., et al. 1997. Proc. Natl. Acad. Sci. USA 94, 73.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision19-April-2011 RFH
      SynonymsN-(3-Indolylmethylene)-isonicotinic Hydrazone
      DescriptionA non-peptidic organic compound that specifically blocks stable CD4-MHC class II binding. Exhibits significant inhibition of immune responses in animal models of autoimmune disease and allograft transplant rejection, suggesting its potential as a novel immunosuppressant. Does not exhibit any toxic effects in vivo, with normal lymphocyte cellularity and subset composition in the spleen and lymph nodes of mice 24 h after injection.
      FormPale yellow solid
      Intert gas (Yes/No) Packaged under inert gas
      CAS number10245-44-0
      Chemical formulaC₁₅H₁₂N₄O
      Structure formulaStructure formula
      Purity≥98% by HPLC (sum of two isomers)
      SolubilityDMSO (5 mg/ml)
      Storage -20°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C).
      Toxicity Standard Handling
      ReferencesLi, S., et al. 1997. Proc. Natl. Acad. Sci. USA 94, 73.