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580551 Tautomycin, Streptomyces spiroverticillatus - CAS 109946-35-2 - Calbiochem

Tautomycin, CAS 109946-35-2, is a potent inhibitor of protein phosphatase 1, 2A, and smooth muscle endogenous phosphatase (IC₅₀ = 1 nM, 10 nM, and 6 nM, respectively). Mixture of two isomers.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Primary Target: PP1
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580551
  
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      Overview

      Replacement Information

      Key Specifications Table

      CAS #Empirical Formula
      109946-35-2C₄₁H₆₆O₁₃
      Description
      OverviewMixture of two isomers. Potent inhibitor of protein phosphatases. Inhibits protein phosphatase 1 (IC50 = 1 nM), protein phosphatase 2A (IC50 = 10 nM), and smooth muscle endogenous phosphatase (IC50 = 6 nM). Higher concentrations are needed to inhibit protein phosphatase 2B. Does not inhibit protein phosphatase 2C.
      Catalogue Number580551
      Brand Family Calbiochem®
      References
      ReferencesMcCluskey, A., et al. 2002. J. Med. Chem. 45, 1151.
      Mitsuhashi, S., et al. 2001. Biochem. Biophys. Res. Commun. 287, 328.
      Kikuchi, K., et al. 1999. Int. J. Mol. Med. 4, 395.
      Sheppeck, J.E., et al. 1997. J. Org. Chem. 62, 387.
      Sugiyama, Y., et al. 1996. Bioorg. Med. Chem. Lett. 6, 3.
      Gong, M.C., et al. 1992. J. Biol. Chem. 267, 14662.
      Suganuma, M., et al. 1992. Toxicon 30, 873.
      MacKintosh, C. and Klumpp, S. 1990. FEBS Lett. 277, 137.
      Magae, J., et al. 1989. J. Antibiot. 42, 1290.
      Product Information
      CAS number109946-35-2
      ATP CompetitiveN
      FormLyophilized thin film
      Hill FormulaC₄₁H₆₆O₁₃
      Chemical formulaC₄₁H₆₆O₁₃
      ReversibleN
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetPP1
      Primary Target IC<sub>50</sub>1 nM, 10 nM, 6 nM, against protein phosphatase 1, protein phosphatase 2A, and smooth muscle endogenous phosphatase, respectively
      Purity≥97% by HPLC
      Physicochemical Information
      Cell permeableN
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      RTECSWX1000000
      Safety Information
      R PhraseR: 26/27/28

      Very toxic by inhalation, in contact with skin and if swallowed.
      S PhraseS: 22-36/37/39-45

      Do not breathe dust.
      Wear suitable protective clothing, gloves and eye/face protection.
      In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Highly Toxic
      Hazardous Materials Attention: Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
      Storage -20°C
      Protect from Light Protect from light
      Protect from Moisture Protect from moisture
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.



      From Catalog:
      Desc. Field- removed ". . .and useful for studies involving protein phosphorylation"
      - removed ". . .or phorbol dibutyrate binding. Does not activate protein kinase C or inhibit myosin light chain kinase
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalog Number GTIN
      580551 0

      Documentation

      Tautomycin, Streptomyces spiroverticillatus - CAS 109946-35-2 - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      Tautomycin, Streptomyces spiroverticillatus - CAS 109946-35-2 - Calbiochem Certificates of Analysis

      TitleLot Number
      580551

      References

      Reference overview
      McCluskey, A., et al. 2002. J. Med. Chem. 45, 1151.
      Mitsuhashi, S., et al. 2001. Biochem. Biophys. Res. Commun. 287, 328.
      Kikuchi, K., et al. 1999. Int. J. Mol. Med. 4, 395.
      Sheppeck, J.E., et al. 1997. J. Org. Chem. 62, 387.
      Sugiyama, Y., et al. 1996. Bioorg. Med. Chem. Lett. 6, 3.
      Gong, M.C., et al. 1992. J. Biol. Chem. 267, 14662.
      Suganuma, M., et al. 1992. Toxicon 30, 873.
      MacKintosh, C. and Klumpp, S. 1990. FEBS Lett. 277, 137.
      Magae, J., et al. 1989. J. Antibiot. 42, 1290.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision12-September-2008 RFH
      DescriptionMixture of two isomers. Potent inhibitor of protein phosphatases and useful for studies involving protein phosphorylation. Inhibits protein phosphatase 1 (IC50 = 1 nM), protein phosphatase 2A (IC50 = 10 nM), and smooth muscle endogenous phosphatase (IC50 = 6 nM). Higher concentrations are needed to inhibit protein phosphatase 2B. Does not inhibit protein phosphatase 2C or phorbol dibutyrate binding. Does not activate protein kinase C or inhibit myosin light chain kinase.
      FormLyophilized thin film
      CAS number109946-35-2
      RTECSWX1000000
      Chemical formulaC₄₁H₆₆O₁₃
      Structure formulaStructure formula
      Purity≥97% by HPLC
      SolubilityChloroform, ethanol, or methanol
      Storage Protect from moisture
      Protect from light
      -20°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.



      From Catalog:
      Desc. Field- removed ". . .and useful for studies involving protein phosphorylation"
      - removed ". . .or phorbol dibutyrate binding. Does not activate protein kinase C or inhibit myosin light chain kinase
      Toxicity Highly Toxic
      ReferencesMcCluskey, A., et al. 2002. J. Med. Chem. 45, 1151.
      Mitsuhashi, S., et al. 2001. Biochem. Biophys. Res. Commun. 287, 328.
      Kikuchi, K., et al. 1999. Int. J. Mol. Med. 4, 395.
      Sheppeck, J.E., et al. 1997. J. Org. Chem. 62, 387.
      Sugiyama, Y., et al. 1996. Bioorg. Med. Chem. Lett. 6, 3.
      Gong, M.C., et al. 1992. J. Biol. Chem. 267, 14662.
      Suganuma, M., et al. 1992. Toxicon 30, 873.
      MacKintosh, C. and Klumpp, S. 1990. FEBS Lett. 277, 137.
      Magae, J., et al. 1989. J. Antibiot. 42, 1290.