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676476 VEGF-C, Rat, Recombinant, S. frugiperda

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: Vascular Endothelial Growth Factor-C

676476
  
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      Overview

      Replacement Information

      Key Specifications Table

      Purity
      ≥90% by SDS-PAGE
      Description
      Overview

      This product has been discontinued.





      Recombinant, rat VEGF-C (129-amino acids lacking the N- and C-terminal extensions and containing only the middle third VEGF homology domain) expressed in S. frugiperda insect cells. Forms primarily non-covalent linked dimers that can phosphorylate VEGF-R3 (Flt-4). Its actions are mediated via VEGFR-2 on vascular endothelial cells. VEGF-C has been shown to be involved in the regulation of growth and differentiation of lymphatic endothelium.
      Supplemented with 0.1% BSA or HSA.
      Catalogue Number676476
      Brand Family Calbiochem®
      SynonymsVascular Endothelial Growth Factor-C
      References
      ReferencesAmioka, T., et al. 2002. Eur. J. Cancer 38, 1413.
      Kirkin, V., et al. 2001. Eur. J. Biochem. 268, 5530.
      Mandriota, S.J., et al. 2001. EMBO J. 20, 672.
      Karkkainen, M.J., and Petrova, T.V. 2000. Oncogene 19, 5598.
      Partanen, T.A., et al. 2000. FASEB J. 14, 2087.
      Joukov, V., et al. 1997. EMBO J. 16, 3898.
      Product Information
      FormLyophilized
      Applications
      Biological Information
      Biological activityED₅₀ ≥200 ng/ml as measured by the stimulation of VEGFR-3 phosphorylation in porcine endothelial cells
      Purity≥90% by SDS-PAGE
      Physicochemical Information
      ContaminantsEndotoxin: <0.1 ng/µg VEGF-C
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Blue Ice Only
      Toxicity Standard Handling
      Storage ≤ -70°C
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-70°C). Avoid freeze/thaw cycles of solutions. Stock solutions are stable for up to 3 months at -70°C.
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalog Number GTIN
      676476 0

      Documentation

      VEGF-C, Rat, Recombinant, S. frugiperda SDS

      Title

      Safety Data Sheet (SDS) 

      VEGF-C, Rat, Recombinant, S. frugiperda Certificates of Analysis

      TitleLot Number
      676476

      References

      Reference overview
      Amioka, T., et al. 2002. Eur. J. Cancer 38, 1413.
      Kirkin, V., et al. 2001. Eur. J. Biochem. 268, 5530.
      Mandriota, S.J., et al. 2001. EMBO J. 20, 672.
      Karkkainen, M.J., and Petrova, T.V. 2000. Oncogene 19, 5598.
      Partanen, T.A., et al. 2000. FASEB J. 14, 2087.
      Joukov, V., et al. 1997. EMBO J. 16, 3898.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision16-September-2008 RFH
      SynonymsVascular Endothelial Growth Factor-C
      DescriptionRecombinant, rat VEGF-C (129-amino acids lacking the N- and C-terminal extensions and containing only the middle third VEGF homology domain) expressed in S. frugiperda insect cells. Forms primarily non-covalent linked dimers that can induce phosphorylation of VEGF-R3 (Flt-4). A lymphangiogenic factor that is reported to be involved in the regulation of growth and differentiation of lymphatic endothelium. The rat recombinant VEGF-C includes amino acids 100 (Gly) to 221 (Ile) and additional 7 amino acid linker along with a His•Tag® sequence (6X His). Exhibits approximately 86% homology with human and 97% homology with mouse VEGF-C. The molecular weight ranges from ~18-24 kDa.
      FormLyophilized
      Purity≥90% by SDS-PAGE
      ContaminantsEndotoxin: <0.1 ng/µg VEGF-C
      Biological activityED₅₀ ≥200 ng/ml as measured by the stimulation of VEGFR-3 phosphorylation in porcine endothelial cells
      SolubilityReconstitute to ≥50 µg/ml in sterile PBS containing ≥0.1% HSA or BSA.
      Storage ≤ -70°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-70°C). Avoid freeze/thaw cycles of solutions. Stock solutions are stable for up to 3 months at -70°C.
      Toxicity Standard Handling
      ReferencesAmioka, T., et al. 2002. Eur. J. Cancer 38, 1413.
      Kirkin, V., et al. 2001. Eur. J. Biochem. 268, 5530.
      Mandriota, S.J., et al. 2001. EMBO J. 20, 672.
      Karkkainen, M.J., and Petrova, T.V. 2000. Oncogene 19, 5598.
      Partanen, T.A., et al. 2000. FASEB J. 14, 2087.
      Joukov, V., et al. 1997. EMBO J. 16, 3898.