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676377 Valinomycin, Streptomyces fulvissimus - CAS 2001-95-8 - Calbiochem

A cyclododecadepsi-peptide ionophore antibiotic.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Primary Target: NGF-induced neuronal differentiation
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      Overview

      Replacement Information

      Key Specifications Table

      CAS #Empirical Formula
      2001-95-8C₅₄H₉₀N₆O₁₈
      Description
      OverviewA cyclododecadepsi-peptide ionophore antibiotic. Potassium ionophore of the mobile ion-carrier type that transports alkali metal ions across artificial or biological lipid membranes. Induces K+ conductivity in cell membranes at concentrations as low as 10-8 M. Often used in membrane electrode systems for determining K+ concentration. Uncouples oxidative phosphorylation by binding to sites on membranes rich in sulfhydryl groups. Induces apoptosis in murine thymocytes. Also reported to inhibit NGF-induced neuronal differentiation.
      Catalogue Number676377
      Brand Family Calbiochem®
      References
      ReferencesHarada, H., et al. 1994. Biochim. Biophys. Acta 1220, 310.
      Luvisetto, S., et al. 1994. Biochim. Biophys. Acta 1186, 12.
      Orlov, V.N., et al. 1994. FEBS Lett. 345, 104.
      Acra, S., et al. 1993. Am. J. Physiol. 264, G45.
      Cornet, M., et al. 1993. J. Membr. Biol. 131, 55.
      Deckers, C.L., et al. 1993. Exp. Cell Res. 208, 362.
      Dimroth, P., and Thomer, A. 1993. Biochemistry 32, 1734.
      Opanasenko, V.K., et al. 1992. FEBS Lett. 307, 280.
      Pape, P.C., et al. 1992. J. Physiol. 449, 219.
      Ahmed, S., and Booth, I.R. 1983. Biochem. J. 212, 105.
      Lerner, A., et al. 1982. FEBS Lett. 146, 9.
      Product Information
      CAS number2001-95-8
      ATP CompetitiveN
      FormWhite crystalline solid
      Hill FormulaC₅₄H₉₀N₆O₁₈
      Chemical formulaC₅₄H₉₀N₆O₁₈
      ReversibleN
      Structure formula ImageStructure formula Image
      Quality LevelMQ200
      Applications
      Biological Information
      Primary TargetNGF-induced neuronal differentiation
      Purity≥93% by HPLC
      Physicochemical Information
      Cell permeableN
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      RTECSYV9468000
      Safety Information
      R PhraseR: 26/27/28

      Very toxic by inhalation, in contact with skin and if swallowed.
      S PhraseS: 22-36/37/39-45

      Do not breathe dust.
      Wear suitable protective clothing, gloves and eye/face protection.
      In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Highly Toxic
      Hazardous Materials Attention: Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
      Storage +15°C to +30°C
      Do not freeze Ok to freeze
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalog Number GTIN
      676377 0

      Documentation

      Valinomycin, Streptomyces fulvissimus - CAS 2001-95-8 - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      Valinomycin, Streptomyces fulvissimus - CAS 2001-95-8 - Calbiochem Certificates of Analysis

      TitleLot Number
      676377

      References

      Reference overview
      Harada, H., et al. 1994. Biochim. Biophys. Acta 1220, 310.
      Luvisetto, S., et al. 1994. Biochim. Biophys. Acta 1186, 12.
      Orlov, V.N., et al. 1994. FEBS Lett. 345, 104.
      Acra, S., et al. 1993. Am. J. Physiol. 264, G45.
      Cornet, M., et al. 1993. J. Membr. Biol. 131, 55.
      Deckers, C.L., et al. 1993. Exp. Cell Res. 208, 362.
      Dimroth, P., and Thomer, A. 1993. Biochemistry 32, 1734.
      Opanasenko, V.K., et al. 1992. FEBS Lett. 307, 280.
      Pape, P.C., et al. 1992. J. Physiol. 449, 219.
      Ahmed, S., and Booth, I.R. 1983. Biochem. J. 212, 105.
      Lerner, A., et al. 1982. FEBS Lett. 146, 9.

      Brochure

      Title
      Antibiotics Profiler
      Mitochondrial Metabolism Modulators
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision19-May-2008 RFH
      DescriptionA cyclododecadepsi-peptide ionophore antibiotic. Potassium ionophore that transports alkali metal ions across artificial or biological lipid membranes (Rb+ >K+ >Cs+ >Ag+ >NH4+ >Na+ >Li+). Induces K+ conductivity in cell membranes at concentrations as low as 10 nM. Because of its ability to affect membrane transport of K+ and to create a hydrophobic layer on solid electrodes, it is often used in membrane electrode systems for determining K+ concentration. Useful in studies of K+ transport in mitochondria. Uncouples oxidative phosphorylation by binding to sites on membranes rich in sulfhydryl groups. Induces apoptosis in murine thymocytes. Also reported to inhibit NGF-induced neuronal differentiation.
      FormWhite crystalline solid
      CAS number2001-95-8
      RTECSYV9468000
      Chemical formulaC₅₄H₉₀N₆O₁₈
      Structure formulaStructure formula
      Purity≥93% by HPLC
      SolubilityAcetic acid, CHCl₃, DMSO, or ether
      Storage +15°C to +30°C
      Do Not Freeze Ok to freeze
      Toxicity Highly Toxic
      Merck USA index14, 9910
      ReferencesHarada, H., et al. 1994. Biochim. Biophys. Acta 1220, 310.
      Luvisetto, S., et al. 1994. Biochim. Biophys. Acta 1186, 12.
      Orlov, V.N., et al. 1994. FEBS Lett. 345, 104.
      Acra, S., et al. 1993. Am. J. Physiol. 264, G45.
      Cornet, M., et al. 1993. J. Membr. Biol. 131, 55.
      Deckers, C.L., et al. 1993. Exp. Cell Res. 208, 362.
      Dimroth, P., and Thomer, A. 1993. Biochemistry 32, 1734.
      Opanasenko, V.K., et al. 1992. FEBS Lett. 307, 280.
      Pape, P.C., et al. 1992. J. Physiol. 449, 219.
      Ahmed, S., and Booth, I.R. 1983. Biochem. J. 212, 105.
      Lerner, A., et al. 1982. FEBS Lett. 146, 9.

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      Categories

      Life Science Research > Inhibitors and Biochemicals > Biochemicals > Ionophores
      Life Science Research > Inhibitors and Biochemicals > Small Molecules & Inhibitors > Other Inhibitors of Biological Interest > Mitochondrial Function Inhibitors