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679130 Vitamin E Succinate

Vitamin E Succinate MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: α-Tocopheryl Succinate, VES

Primary Target: PKC activity
679130
  
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      Overview

      Replacement Information

      Key Specifications Table

      CAS #Empirical Formula
      4345-03-3C₃₃H₅₄O₅
      Description
      Overview

      This product has been discontinued.





      Enhances the immune response and induces cellular differentiation and/or growth inhibition. VES has been shown to modulate adenylate cyclase and cAMP-dependent proteins, inhibit protein kinase C activity, bind to a cellular vitamin E binding protein, suppress c-myc and c-H-ras oncogene expression, and regulate TGF-β protein production. Also shown to induce apoptosis in RL cells. Exhibits antioxidant properties.
      Catalogue Number679130
      Brand Family Calbiochem®
      Synonymsα-Tocopheryl Succinate, VES
      References
      ReferencesTurley, J.M., et al. 1995. Cell Growth Differentiation 6, 655.
      Fariss, M.W., et al. 1994. Cancer Res. 54, 3346.
      Cohrs, R.J., et al. 1991. Int. J. Dev. Neurosci. 9, 187.
      Sahu, S.N., and Prasad, K.N. 1988. Cancer 62, 949.
      Product Information
      CAS number4345-03-3
      FormWhite to yellow solid
      Hill FormulaC₃₃H₅₄O₅
      Chemical formulaC₃₃H₅₄O₅
      Applications
      Biological Information
      Biological activityPotency: ≥960 mg/g
      Primary TargetPKC activity
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      RTECSEJ9984000
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage +15°C to +30°C
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalog Number GTIN
      679130 0

      Documentation

      Vitamin E Succinate Certificates of Analysis

      TitleLot Number
      679130

      References

      Reference overview
      Turley, J.M., et al. 1995. Cell Growth Differentiation 6, 655.
      Fariss, M.W., et al. 1994. Cancer Res. 54, 3346.
      Cohrs, R.J., et al. 1991. Int. J. Dev. Neurosci. 9, 187.
      Sahu, S.N., and Prasad, K.N. 1988. Cancer 62, 949.

      Brochure

      Title
      PKC Pathway Poster PDF ( 676 KB )
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision11-January-2010 RFH
      Synonymsα-Tocopheryl Succinate, VES
      DescriptionEnhances the immune response and induces cellular differentiation and/or growth inhibition. Potent and cell-permeable inhibitor of neuroblastoma cells, murine melanoma cells, avian lymphoid cells, human HL-60 promyelocytic leukemia cells, and several human breast carcinoma cell lines. VES has been shown to modulate adenylate cyclase and cAMP-dependent protein, inhibit protein kinase C activity, bind to cellular vitamin E binding protein, suppress c-myc and c-H-ras oncogene expression, and regulate TGFβ protein production. Also shown to induce apoptosis in RL cells. Prevents oxidative damage.
      FormWhite to yellow solid
      CAS number4345-03-3
      RTECSEJ9984000
      Chemical formulaC₃₃H₅₄O₅
      Biological activityPotency: ≥960 mg/g
      SolubilityChloroform (50 mg/ml)
      Storage +15°C to +30°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Standard Handling
      Merck USA index14, 9495
      ReferencesTurley, J.M., et al. 1995. Cell Growth Differentiation 6, 655.
      Fariss, M.W., et al. 1994. Cancer Res. 54, 3346.
      Cohrs, R.J., et al. 1991. Int. J. Dev. Neurosci. 9, 187.
      Sahu, S.N., and Prasad, K.N. 1988. Cancer 62, 949.