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681669 Wnt Antagonist I, IWR-1-endo - Calbiochem

Overview

Key Specifications Table

Empirical Formula
C₂₅H₁₉N₃O₃

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681669-10MG
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      Plastic ampoule 10 mg
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      Description
      OverviewA cell-permeable p-imidobenzamidoquinoline, endo-diastereomer that is shown to inhibit the activity of TNKS1/PARP5a and TNKS2/PARP5b in in vitro auto-PARsylation assays (IC50 = 131 and 56 nM, respectively) and effectively suppress Wnt-stimulated transcription activity in L-Wnt-STF-based reporter assays (IC50 = 180 nM), while exhibiting little activity against PARP1 or PARP2 (IC50 >18.75 µM). Although both IWR-1-endo and XAV939 act as reversible Wnt pathway inhibitors and exhibit similar pharmacological effects both in vitro and in vivo, IWR-1-endo exerts its effect via interaction with Axin, while XAV939 binds TNKS directly. Also available as a 25 mM solution in DMSO (Cat. No. 504462).
      Catalogue Number681669
      Brand Family Calbiochem®
      SynonymsTNKS1/2 Inhibitor II, Inhibitor of Wnt Response-1, Wnt Pathway Inhibitor I, Tankyrase1/2 Inhibitor II
      References
      ReferencesChen, B., et al. 2009. Nature Chem. Biol. 5, 100.
      Huang, S.M., et al. 2009. Nature 461, 614.
      Product Information
      FormOff-white solid
      Hill FormulaC₂₅H₁₉N₃O₃
      Chemical formulaC₂₅H₁₉N₃O₃
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Biological Information
      Purity≥95% by HPLC
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Global Trade Item Number
      Catalog Number GTIN
      681669-10MG 04055977260274