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  • RIP | Life Science Research | MilliporeSigma

    RNA-binding protein immunoprecipitation (RIP) is the RNA analog of the ChIP application (chromatin immunoprecipitation). It can be used to identify specific RNA molecules (of many types) associated with specific nuclear or cytoplasmic binding proteins.

  • Histone Modifications | Life Science Research | MilliporeSigma

    Histone modifications regulate DNA transcription, repair, recombination, and replication, and can alter local chromatin architecture. The most commonly studied histone modifications are acetylation, phosphorylation, methylation, and ubiquitination.

  • Histone Peptide Arrays | Life Science Research | MilliporeSigma

    Histone peptide arrays are essential screening tools to evaluate the specificity and cross-reactivity of antibodies against histones H2A, H2B, H3, H4, and their post-translational modifications.The arrays are designed on PVDF membranes for a simple Western blot-like assay.

  • TFA | Life Science Research | MilliporeSigma

    Transcription or posttranscriptional regulation (TFA) gene change affects the level or localization of protein expression. Characterization of the regulatory machinery is essential for understanding and potentially modulating biological responses encoded in genomic (and epigenomic) information.

  • Genomic instability | Life Science Research | MilliporeSigma

    Learn about the environmental factors that can hinder DNA repair. There are many evidence linking genomic and epigenomic changes to disorders involving accelerated aging. Evidence points to general physiological stress and disrupted circadian. It is also possible that decreased DNA repair is also a symptom, not a cause, of aging. To investigate this possibility, researchers will need to examine changes in transcriptional regulators of repair genes, such as ncRNAs, hormones, and other chromatin modulators.

  • ChIP Kits | Life Science Research | MilliporeSigma

    ChIP kits selection guide provides you with more information and details about each type of ChiPs : Description, Number of assays, Assay time, Availability with protein A or G, Agarose or Magnetic, etc..