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530729 AAA-ATPase Drg1 Inhibitor, Diazaborine - CAS 22959-81-5 - Calbiochem

An anti-bacterial compound that targets NAD(P)H-dependent enoyl acyl carrier protein reductase (ENR) resulting in the inhibition of bacterial fatty acid synthase.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: 2-tosylbenzo[d][1,2,3]diazaborinin-1(2H)-ol, Ribosome Biogenesis Inhibitor, Diazaborine, Drg1 inhibitor

Primary Target: Drg1 AAA-ATPase
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530729
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Overview

Replacement Information

Key Specifications Table

CAS #Empirical Formula
22959-81-5C₁₄H₁₃BN₂O₃S

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      Description
      OverviewA diazaborine derivative with anti-bacterial properties against a wide range of Gram-negative bacteria. Shown to target NAD(P)H-dependent enoyl acyl carrier protein reductase (ENR), which results in the inhibition of bacterial fatty acid synthase. Blocks the maturation of ribosomal RNA for the large 60S ribosomal subunit in yeast cells by binding to the D2 domain of AAA-ATPase Drg1 (Ki = 26 µM) resulting in reduced ATP hydrolysis and release of Rip24 from pre-60S particles.

      Please note that the molecular weight for this compound is batch-specific due to variable water content.
      Catalogue Number530729
      Brand Family Calbiochem®
      Synonyms2-tosylbenzo[d][1,2,3]diazaborinin-1(2H)-ol, Ribosome Biogenesis Inhibitor, Diazaborine, Drg1 inhibitor
      References
      ReferencesLoibl, M., et al. 2014. J. Biol. Chem. 289, 3913.
      Pertschy B., et al. 2004. Mol. Cell. Biol. 24, 6476.
      Baldock, C. et al. 1998. Biochem. Pharmacol. 55, 1541.
      Grassberger M., et al. 1984. J Med Chem. 27, 947.
      Product Information
      CAS number22959-81-5
      FormWhite powder
      Hill FormulaC₁₄H₁₃BN₂O₃S
      Chemical formulaC₁₄H₁₃BN₂O₃S
      ReversibleY
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetDrg1 AAA-ATPase
      Primary Target K<sub>i</sub>26 µ
      Purity≥98% by HPLC
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalog Number GTIN
      5.30729.0001 04055977260458

      Documentation

      AAA-ATPase Drg1 Inhibitor, Diazaborine - CAS 22959-81-5 - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      References

      Reference overview
      Loibl, M., et al. 2014. J. Biol. Chem. 289, 3913.
      Pertschy B., et al. 2004. Mol. Cell. Biol. 24, 6476.
      Baldock, C. et al. 1998. Biochem. Pharmacol. 55, 1541.
      Grassberger M., et al. 1984. J Med Chem. 27, 947.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision27-June-2014 JSW
      Synonyms2-tosylbenzo[d][1,2,3]diazaborinin-1(2H)-ol, Ribosome Biogenesis Inhibitor, Diazaborine, Drg1 inhibitor
      DescriptionA diazaborine derivative with anti-bacterial properties against a wide range of Gram-negative bacteria. Shown to target NAD(P)H-dependent enoyl acyl carrier protein reductase (ENR), which results in the inhibition of bacterial fatty acid synthase. Blocks the maturation of ribosomal RNA for the large 60S ribosomal subunit in yeast cells by binding to the D2 domain of AAA-ATPase Drg1 (Ki = 26 µM) resulting in reduced ATP hydrolysis and release of Rip24 from pre-60S particles.
      FormWhite powder
      Intert gas (Yes/No) Packaged under inert gas
      CAS number22959-81-5
      Chemical formulaC₁₄H₁₃BN₂O₃S
      Purity≥98% by HPLC
      SolubilityDMSO (100 mg/ml)
      Storage Protect from light
      +2°C to +8°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Standard Handling
      ReferencesLoibl, M., et al. 2014. J. Biol. Chem. 289, 3913.
      Pertschy B., et al. 2004. Mol. Cell. Biol. 24, 6476.
      Baldock, C. et al. 1998. Biochem. Pharmacol. 55, 1541.
      Grassberger M., et al. 1984. J Med Chem. 27, 947.