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MAB2056Z Anti-Integrin α3 Antibody, clone ASC-1 (Azide Free)

Anti-Integrin α3 Antibody, clone ASC-1 (Azide Free) inhibits cell attachment & detects level of Integrin α3 & has been published & validated for use in FC, IP, IH, Inhibition Assays.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Research Category: Cell Structure Research Sub-Category: Integrins Gene Symbol: ITGA3, GAP-B3, CD49c, FLJ34704, MSK18, VLA3a, VL3A, VCA-2, FLJ34631, FRP-2, GAPB3, CD49C UniProt Number: P26006
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MAB2056Z
100 µg  
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      Overview

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      Key Specifications Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      HFC, IP, IHC, FUNCMPurifiedMonoclonal Antibody
      Description
      Catalogue NumberMAB2056Z
      Brand Family Chemicon®
      Trade Name
      • Chemicon
      DescriptionAnti-Integrin α3 Antibody, clone ASC-1 (Azide Free)
      Alternate Names
      • CD49c
      References
      Product Information
      FormatPurified
      PresentationPurified cultured supernatant in PBS without preservatives
      Quality LevelMQ100
      Applications
      ApplicationAnti-Integrin α3 Antibody, clone ASC-1 (Azide Free) inhibits cell attachment & detects level of Integrin α3 & has been published & validated for use in FC, IP, IH, Inhibition Assays.
      Key Applications
      • Flow Cytometry
      • Immunoprecipitation
      • Immunohistochemistry
      • Affects Function
      Application NotesInhibition (Functional Activity): A previous lot of this antibody was shown to inhibit cell attachment by inhibiting SCC9 cell adhesion to human and EHS laminin, and laminin GD-2 peptide and potentiates the inhibition of SKOV-3 cell adhesion to EHS laminin by anti-integrin alpha 5 antibody GoH3. This antibody does not inhibit cell adhesion to fibronectin or collagen type IV.

      Immunohistochemistry Analysis: A previous lot of this antibody was used on acetone-fixed frozen human epithelial tissues including tongue, foreskin and ovary. Not for use on formalin-fixed tissue.

      Flow Cytometry Analysis: A previous lot of this antibody stains human squamous cell carcinoma (SCC9), ovarian carcinoma (SKOV-3) and umbilical vein endothelial cells (HUVEC).

      Immunoprecipitation Analysis: A previous lot of this antibody precipitates PAGE bands of 130 kDa (reduced) or 116 kDa and 135 kDa (non-reduced) from surface-biotinylated SCC9 or SKOV-3 cells.
      Biological Information
      ImmunogenHuman squamous cell carcinoma cells (SCC9)
      CloneASC-1
      ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
      HostMouse
      SpecificityHuman alpha3 integrin (CD49c)
      IsotypeIgG1κ
      Species Reactivity
      • Human
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Entrez Gene SummaryITGA3 encodes the integrin alpha 3 chain. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. Alpha chain 3 undergoes post-translational cleavage in the extracellular domain to yield disulfide-linked light and heavy chains that join with beta 1 to form an integrin that interacts with many extracellular-matrix proteins. The alpha 3 beta 1 integrin is known variously as: very late (activation) antigen 3 ('VLA-3'), very common antigen 2 ('VCA-2'), extracellular matrix receptor 1 ('ECMR1'), and galactoprotein b3 ('GAPB3').
      Gene Symbol
      • ITGA3
      • GAP-B3
      • CD49c
      • FLJ34704
      • MSK18
      • VLA3a
      • VL3A
      • VCA-2
      • FLJ34631
      • FRP-2
      • GAPB3
      • CD49C
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: P26006 # Integrin alpha-3/beta-1 is a receptor for fibronectin, laminin, collagen, epiligrin, thrombospondin and CSPG4. Alpha- 3/beta-1 may mediate with LGALS3 the stimulation by CSPG4 of endothelial cells migration.
      SIZE: 1066 amino acids; 118698 Da
      SUBUNIT: Heterodimer of an alpha and a beta subunit. The alpha subunit is composed of an heavy and a light chain linked by a disulfide bond. Alpha-3 associates with beta-1. Interacts with HPS5.
      SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.
      TISSUE SPECIFICITY: Isoform alpha-3A is widely expressed. Isoform alpha-3B is expressed in brain and heart. In brain, both isoforms are exclusively expressed on vascular smooth muscle cells, whereas in heart isoform alpha-3A is strongly expressed on vascular smooth muscle cells, isoform alpha-3B is detected only on endothelial vein cells.
      PTM: Isoform alpha-3A, but not isoform alpha-3B, is phosphorylated on serine residues. Phosphorylation increases after phorbol 12- myristate 13-acetate stimulation.
      SIMILARITY: SwissProt: P26006 ## Belongs to the integrin alpha chain family. & Contains 7 FG-GAP repeats.
      Molecular Weight116 kDa
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStore at -20°C in undiluted aliquots.
      Avoid repeated freeze-thaw cycles.
      Packaging Information
      Material Size100 µg
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalog Number GTIN
      MAB2056Z 04053252939600

      Documentation

      Anti-Integrin α3 Antibody, clone ASC-1 (Azide Free) SDS

      Title

      Safety Data Sheet (SDS) 

      Anti-Integrin α3 Antibody, clone ASC-1 (Azide Free) Certificates of Analysis

      TitleLot Number
      Anti-Integrin 3, clone ASC-1 (Azide Free) - Q2350728 Q2350728
      Anti-Integrin α3, clone ASC-1 (Azide Free) 3073835
      Anti-Integrin α3, clone ASC-1 (Azide Free) - 3507303 3507303
      Anti-Integrin α3, clone ASC-1 (Azide Free) - 3510865 3510865
      Anti-Integrin α3, clone ASC-1 (Azide Free) - 3583882 3583882
      Anti-Integrin α3, clone ASC-1 (Azide Free) -2771832 2771832
      Anti-Integrin α3, clone ASC-1 (Azide Free) Monoclonal Antibody 3147030

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      Categories

      Life Science Research > Antibodies and Assays > Primary Antibodies