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324890 E-64 Protease Inhibitor - CAS 66701-25-5 - Calbiochem

E-64 Protease Inhibitor, CAS 66701-25-5, is an irreversible inhibitor of cysteine proteases. Interacts with the Sn subsites of proteases. Has no action on cysteine residues in other proteins.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: (2R,3R)-3-((S)-1-(4-Guanidinobutylamino)-4-methyl-1-oxopentan-2-ylcarbamoyl)oxirane-2-carboxylic acid, trans-Epoxysuccinyl-L-​leucylamido(4-​guanidino)​butane, L-trans-​3-​Carboxyoxiran-​2-​carbonyl-L-leucylagmatine, N-​(trans-​Epoxysuccinyl)​-L-leucine 4-​guanidinobutylamide

Primary Target: cysteine proteases
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Overview

Replacement Information

Key Specifications Table

CAS #Empirical Formula
66701-25-5C₁₅H₂₇N₅O₅

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      324890-25MG
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              Description
              OverviewIrreversible inhibitor of cysteine proteases. Interacts with the Sn subsites of proteases. Has no action on cysteine residues in other proteins. Inhibits activation-induced programmed cell death and restores defective immune responses in HIV+ donors. Specific active site titrant.
              Catalogue Number324890
              Brand Family Calbiochem®
              Synonyms(2R,3R)-3-((S)-1-(4-Guanidinobutylamino)-4-methyl-1-oxopentan-2-ylcarbamoyl)oxirane-2-carboxylic acid, trans-Epoxysuccinyl-L-​leucylamido(4-​guanidino)​butane, L-trans-​3-​Carboxyoxiran-​2-​carbonyl-L-leucylagmatine, N-​(trans-​Epoxysuccinyl)​-L-leucine 4-​guanidinobutylamide
              References
              ReferencesMatsumoto, K., et al. 1999. Biopolymers 51, 99.
              Sarin, A., et al. 1994. J. Immunol. 153, 862.
              Sarin, A., et al. 1993. J. Exp. Med. 178, 1693.
              Barrett, A.J. 1982. Biochem. J. 201, 189.
              Product Information
              CAS number66701-25-5
              ATP CompetitiveN
              FormWhite solid
              Hill FormulaC₁₅H₂₇N₅O₅
              Chemical formulaC₁₅H₂₇N₅O₅
              ReversibleN
              Structure formula ImageStructure formula Image
              Quality LevelMQ200
              Applications
              ApplicationE-64 Protease Inhibitor, CAS 66701-25-5, is an irreversible inhibitor of cysteine proteases. Interacts with the Sn subsites of proteases. Has no action on cysteine residues in other proteins.
              Biological Information
              Primary Targetcysteine proteases
              Purity≥98% by HPLC
              Physicochemical Information
              Cell permeableN
              Dimensions
              Materials Information
              Toxicological Information
              Safety Information according to GHS
              RTECSRR0390000
              Safety Information
              Product Usage Statements
              Storage and Shipping Information
              Ship Code Ambient Temperature Only
              Toxicity Standard Handling
              Storage -20°C
              Do not freeze Ok to freeze
              Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 4 months at -20°C.
              Packaging Information
              Transport Information
              Supplemental Information
              Specifications
              Global Trade Item Number
              Catalog Number GTIN
              324890-1MG 04055977196146
              324890-25MG 04055977196160
              324890-5MG 04055977196177

              Documentation

              E-64 Protease Inhibitor - CAS 66701-25-5 - Calbiochem SDS

              Title

              Safety Data Sheet (SDS) 

              E-64 Protease Inhibitor - CAS 66701-25-5 - Calbiochem Certificates of Analysis

              TitleLot Number
              324890

              References

              Reference overview
              Matsumoto, K., et al. 1999. Biopolymers 51, 99.
              Sarin, A., et al. 1994. J. Immunol. 153, 862.
              Sarin, A., et al. 1993. J. Exp. Med. 178, 1693.
              Barrett, A.J. 1982. Biochem. J. 201, 189.

              Citations

              Title
            • Ok Hee Ryu, et al. (2005) Proteolysis of MIP-1α isoforms LD78β and LD78α by neutrophil-derived serine proteases. Journal of Biological Chemistry 280, 17415-17421.
              		•
              Data Sheet

              Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

              Revision12-July-2013 JSW
              Synonyms(2R,3R)-3-((S)-1-(4-Guanidinobutylamino)-4-methyl-1-oxopentan-2-ylcarbamoyl)oxirane-2-carboxylic acid, trans-Epoxysuccinyl-L-​leucylamido(4-​guanidino)​butane, L-trans-​3-​Carboxyoxiran-​2-​carbonyl-L-leucylagmatine, N-​(trans-​Epoxysuccinyl)​-L-leucine 4-​guanidinobutylamide
              DescriptionIrreversible inhibitor of cysteine proteases. Has no action on cysteine residues in other proteins. Inhibits activation-induced programmed cell death and restores defective immune responses in HIV+ donors. Specific active site titrant.
              FormWhite solid
              CAS number66701-25-5
              RTECSRR0390000
              Chemical formulaC₁₅H₂₇N₅O₅
              Structure formulaStructure formula
              Purity≥98% by HPLC
              SolubilityDMSO (25 mg/ml) or H₂O (20 mg/ml)
              Storage -20°C
              Do Not Freeze Ok to freeze
              Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 4 months at -20°C.
              Toxicity Standard Handling
              ReferencesMatsumoto, K., et al. 1999. Biopolymers 51, 99.
              Sarin, A., et al. 1994. J. Immunol. 153, 862.
              Sarin, A., et al. 1993. J. Exp. Med. 178, 1693.
              Barrett, A.J. 1982. Biochem. J. 201, 189.
              Citation
            • Ok Hee Ryu, et al. (2005) Proteolysis of MIP-1α isoforms LD78β and LD78α by neutrophil-derived serine proteases. Journal of Biological Chemistry 280, 17415-17421.
              		•