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500583 Sigma-AldrichInSolution™ (+)-Brefeldin A, Eupenicillium brefeldianum - CAS 20350-15-6 - Calbiochem

A 25 mM solution of (+)-Brefeldin A in DMSO.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

SDS
References
Data Sheet

Synonyms: 1,6,7,8,9,11a,12,13,14,14a-Decahydro-1,13-dihydroxy-6-methyl-4H-cyclopent[f]oxacyclotridecin-4-one, (1S,2E,7S,10E,12R,13R,15S)-12,15-dihydroxy-7-methyl-8-oxabicyclo[11.3.0]hexadeca-2,10-dien-9-one, CID 5287620, Cyanaein

Primary Target: ADP-ribosylation factor (ARF)

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Overview

Replacement Information

Key Specifications Table

CAS #	Empirical Formula
20350-15-6	C₁₆H₂₄O₄

Pricing & Availability

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5.00583.0001	Retrieving availability... — Limited Availability Stocked Discontinued Limited Quantities Available Available Login to See Inventory Stocked Limited Availability Stocked Remaining : Will advise Remaining : Will advise Will advise Contact Customer Service Contact Customer Service Contact Customer Service Contact Customer Service	Glass bottle	2 mg	Retrieving price... Price could not be retrieved Minimum Quantity is a multiple of Maximum Quantity is Upon Order Completion More Information You Saved () — Request Pricing Login to See Your Pricing	Check Availability —	Add To Favorites Add To Favorites Added To My Favorites

Description
Catalogue Number	500583
Brand Family	Calbiochem®
Synonyms	1,6,7,8,9,11a,12,13,14,14a-Decahydro-1,13-dihydroxy-6-methyl-4H-cyclopent[f]oxacyclotridecin-4-one, (1S,2E,7S,10E,12R,13R,15S)-12,15-dihydroxy-7-methyl-8-oxabicyclo[11.3.0]hexadeca-2,10-dien-9-one, CID 5287620, Cyanaein

References
References	Yamagi, R., et al. 2000. Proc. Natl. Acad. Sci. USA 97, 2567. Moriango, N., et al. 1996. Proc. Natl. Acad. Sci. USA 93, 12856. Mendez, A.J. 1995. J. Biol. Chem. 270, 5891. Ridgway, N.D., et al. 1995. J. Biol. Chem.270, 8023. Tsai, S.C., et al. 1994. Proc. Natl. Acad. Sci. USA 91, 3063. Ktistakis, N.Y., et al. 1992. Nature 356, 344.

Product Information
CAS number	20350-15-6
Form	Liquid
Formulation	A 25 mM (2 mg/285 µL) solution of (+)-Brefeldin A (Cat. No. 203729) in DMSO.
Hill Formula	C₁₆H₂₄O₄
Chemical formula	C₁₆H₂₄O₄
Hygroscopic	Hygroscopic
Reversible	Y
Structure formula Image
Quality Level	MQ100

Applications

Biological Information
Primary Target	ADP-ribosylation factor (ARF)
Purity	≥95% by HPLC

Physicochemical Information
Cell permeable	Y

Dimensions

Materials Information

Toxicological Information

Safety Information according to GHS

Safety Information
R Phrase	R: 36/38 Irritating to eyes and skin.
S Phrase	S: 26-36 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing.

Product Usage Statements

Storage and Shipping Information
Ship Code	Dry Ice Only
Toxicity	Irritant
Storage	≤ -70°C
Protect from Light	Protect from light
Hygroscopic	Hygroscopic
Avoid freeze/thaw	Avoid freeze/thaw
Do not freeze	Ok to freeze
Special Instructions	Following initial thaw, aliquot and freeze (-70°C). Aliquots are stable for up to 6 months at -70°C. Use only fresh DMSO for further dilutions prior to use.

Packaging Information
Packaged under inert gas	Packaged under inert gas

Transport Information

Supplemental Information

Specifications

Global Trade Item Number
Catalog Number	GTIN
5.00583.0001	04055977244984

Documentation

InSolution™ (+)-Brefeldin A, Eupenicillium brefeldianum - CAS 20350-15-6 - Calbiochem SDS

Title
Safety Data Sheet (SDS)

References

Reference overview
Yamagi, R., et al. 2000. Proc. Natl. Acad. Sci. USA 97, 2567. Moriango, N., et al. 1996. Proc. Natl. Acad. Sci. USA 93, 12856. Mendez, A.J. 1995. J. Biol. Chem. 270, 5891. Ridgway, N.D., et al. 1995. J. Biol. Chem.270, 8023. Tsai, S.C., et al. 1994. Proc. Natl. Acad. Sci. USA 91, 3063. Ktistakis, N.Y., et al. 1992. Nature 356, 344.

Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision	11-July-2014 JSW
Synonyms	1,6,7,8,9,11a,12,13,14,14a-Decahydro-1,13-dihydroxy-6-methyl-4H-cyclopent[f]oxacyclotridecin-4-one, (1S,2E,7S,10E,12R,13R,15S)-12,15-dihydroxy-7-methyl-8-oxabicyclo[11.3.0]hexadeca-2,10-dien-9-one, CID 5287620, Cyanaein
Description	Specifically and reversibly blocks translocation of proteins from the endoplasmic reticulum (ER) to the Golgi apparatus without affecting endocytosis or lysosome function. Inhibitor of HDL-mediated cholesterol efflux. Causes disassembly of the Golgi complex and ER swelling in a variety of mammalian cell lines at <40 ng/ml. Inhibits the activity of BIG1 and BIG2, the guanine-nucleotide exchange proteins for ADP-ribosylation factors. Blocks binding of ADP-ribosylation factor to the Golgi and inhibits the GDP-GTP exchange.
Form	Liquid
Formulation	A 25 mM (2 mg/285 µL) solution of (+)-Brefeldin A (Cat. No. 203729) in DMSO.
Intert gas (Yes/No)	Packaged under inert gas
CAS number	20350-15-6
Chemical formula	C₁₆H₂₄O₄
Structure formula
Purity	≥95% by HPLC
Storage	Protect from light Avoid freeze/thaw ≤ -70°C Hygroscopic
Do Not Freeze	Ok to freeze
Special Instructions	Following initial thaw, aliquot and freeze (-70°C). Aliquots are stable for up to 6 months at -70°C. Use only fresh DMSO for further dilutions prior to use.
Toxicity	Irritant
References	Yamagi, R., et al. 2000. Proc. Natl. Acad. Sci. USA 97, 2567. Moriango, N., et al. 1996. Proc. Natl. Acad. Sci. USA 93, 12856. Mendez, A.J. 1995. J. Biol. Chem. 270, 5891. Ridgway, N.D., et al. 1995. J. Biol. Chem.270, 8023. Tsai, S.C., et al. 1994. Proc. Natl. Acad. Sci. USA 91, 3063. Ktistakis, N.Y., et al. 1992. Nature 356, 344.

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