559388 Sigma-AldrichSB 202190 - CAS 152121-30-7 - Calbiochem
SB 202190, CAS 152121-30-7, is a potent, reversible, competitive inhibitor of p38. Inhibits p38 phosphorylation of myelin basic protein. Blocks the activity of p38β (Ki = 16 nM; IC₅₀ = 350 nM).
More>> SB 202190, CAS 152121-30-7, is a potent, reversible, competitive inhibitor of p38. Inhibits p38 phosphorylation of myelin basic protein. Blocks the activity of p38β (Ki = 16 nM; IC₅₀ = 350 nM). Less<<SB 202190 - CAS 152121-30-7 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Synonyms: 4-(4-Fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)1H-imidazole, FHPI, p38 MAP Kinase Inhibitor II
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Overview
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Key Specifications Table
| CAS # | Empirical Formula |
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| 152121-30-7 | C₂₀H₁₄FN₃O |
Pricing & Availability
| Catalog Number | Availability | Packaging | Qty/Pack | Price | Quantity | |
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| 559388-1MG |
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Plastic ampoule | 1 mg |
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| Description | |
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| Overview | A potent, reversible, competitive, and cell-permeable inhibitor of p38 MAP kinase. Inhibits p38 phosphorylation of myelin basic protein (MBP) with no effect on the activity of the ERK or JNK MAP kinase subgroups. Also inhibits the kinase activity of p38β (Ki = 16 nM; IC50 = 350 nM) and p38 phosphorylation of activating transcription factor 2 (ATF-2; IC50 = 280 nM). Blocks LPS-induced TNF-α and interleukin biosynthesis. Reported to induce LDL receptor expression in Hep52 cells. A 1 mg/ml solution of SB 202190 (Cat. No. 559397) in anhydrous DMSO is also available. |
| Catalogue Number | 559388 |
| Brand Family | Calbiochem® |
| Synonyms | 4-(4-Fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)1H-imidazole, FHPI, p38 MAP Kinase Inhibitor II |
| Product Information | |
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| CAS number | 152121-30-7 |
| ATP Competitive | Y |
| Form | Pale yellow solid |
| Hill Formula | C₂₀H₁₄FN₃O |
| Chemical formula | C₂₀H₁₄FN₃O |
| Reversible | Y |
| Structure formula Image | |
| Quality Level | MQ100 |
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| Physicochemical Information | |
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| Cell permeable | Y |
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| Specifications |
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| Global Trade Item Number | |
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| Catalog Number | GTIN |
| 559388-1MG | 04055977192476 |
Documentation
SB 202190 - CAS 152121-30-7 - Calbiochem SDS
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SB 202190 - CAS 152121-30-7 - Calbiochem Certificates of Analysis
| Title | Lot Number |
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| 559388 |
References
| Reference overview |
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| Davies, S.P., et al. 2000. Biochem. J. 351, 95. Ajizian, S.J., et al. 1999. J. Infect. Dis. 179, 939. Singh, R.P., et al. 1999. J. Biol. Chem. 274, 19593. Wang, S.W., et al. 1999. Inflamm. Res. 48, 533. Gallagher, T.F., et al. 1997. Bioorg. Med. Chem. 5, 49. LoGrasso, P.V., et al. 1997. Biochem. 36, 10422. Jiang, Y., et al. 1996. J. Biol. Chem. 271, 17920. Kramer, R.M., et al. 1996. J. Biol. Chem. 271, 27723. Li, Z., et al. 1996. Biochem. Biophys. Res. Commun. 228, 334. Lee, J.C., et al. 1994. Nature 372, 739. |
Brochure
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| MAPK Pathway Poster ( 750 KB ) |
Citations
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| Data Sheet | ||||||||||||||||||||||||||||||
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Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.
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