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100105 A23187, Free Acid, Streptomyces chartreusensis - CAS 52665-69-7 - Calbiochem

A mobile ion-carrier that forms stable complexes with divalent cations.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: Calcimycin

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100105
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Overview

Replacement Information

Key Specifications Table

CAS #Empirical Formula
52665-69-7C₂₉H₃₇N₃O₆

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      100105-1MG
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          100105-5MG
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              Description
              OverviewA mobile ion-carrier that forms stable complexes with divalent cations. Useful for increasing intracellular Ca2+ levels. Also acts as an uncoupler of oxidative phosphorylation and inhibitor of mitochondrial ATPase activity. An antibiotic with weak activity against Gram-positive bacteria. Also induces apoptosis in mouse lymphoma cell line (S49); however, A23187 has been shown to block apoptosis in other systems, such as when interleukin-3 (IL-3) is withdrawn from IL-3-dependent cells.
              Catalogue Number100105
              Brand Family Calbiochem®
              SynonymsCalcimycin
              References
              ReferencesCaron-Leslie, L.A., et al. 1994. FASEB J. 8, 639.
              Saunders, M.J., and Hepler, P.K. 1982. Science 217, 943.
              Pressman, B.C. 1976. Annu. Rev. Biochem. 45, 501.
              Pfeiffer, D.R., et al. 1974. Biochemistry 13, 4007.
              Reed, P.W., and Lardy, H.A. 1972. J. Biol. Chem. 247, 6970.
              Product Information
              CAS number52665-69-7
              ATP CompetitiveN
              FormWhite solid
              Hill FormulaC₂₉H₃₇N₃O₆
              Chemical formulaC₂₉H₃₇N₃O₆
              ReversibleN
              Structure formula ImageStructure formula Image
              Quality LevelMQ100
              Applications
              Biological Information
              Primary TargetMitochondrial ATPase
              Purity≥98% by TLC
              Physicochemical Information
              Cell permeableN
              Dimensions
              Materials Information
              Toxicological Information
              Safety Information according to GHS
              RTECSDM4676000
              Safety Information
              Product Usage Statements
              Storage and Shipping Information
              Ship Code Ambient Temperature Only
              Toxicity Standard Handling
              Storage +2°C to +8°C
              Protect from Light Protect from light
              Do not freeze Ok to freeze
              Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 2 months at -20°C.
              Packaging Information
              Transport Information
              Supplemental Information
              Specifications
              Global Trade Item Number
              Catalog Number GTIN
              100105-10MG 04055977226232
              100105-1MG 04055977226225
              100105-5MG 04055977226249

              Documentation

              A23187, Free Acid, Streptomyces chartreusensis - CAS 52665-69-7 - Calbiochem SDS

              Title

              Safety Data Sheet (SDS) 

              A23187, Free Acid, Streptomyces chartreusensis - CAS 52665-69-7 - Calbiochem Certificates of Analysis

              TitleLot Number
              100105

              References

              Reference overview
              Caron-Leslie, L.A., et al. 1994. FASEB J. 8, 639.
              Saunders, M.J., and Hepler, P.K. 1982. Science 217, 943.
              Pressman, B.C. 1976. Annu. Rev. Biochem. 45, 501.
              Pfeiffer, D.R., et al. 1974. Biochemistry 13, 4007.
              Reed, P.W., and Lardy, H.A. 1972. J. Biol. Chem. 247, 6970.
              Data Sheet

              Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

              Revision07-April-2008 RFH
              SynonymsCalcimycin
              DescriptionA mobile ion-carrier that forms stable complexes with divalent cations. Useful for increasing intracellular Ca2+ levels. Also acts as an uncoupler of oxidative phosphorylation and inhibitor of mitochondrial ATPase activity. An antibiotic with weak activity against Gram positive bacteria. Also induces apoptosis in mouse lymphoma cell line (S49); however, A23187 has been shown to block apoptosis in other systems, such as when interleukin-3 (IL-3) is withdrawn from IL-3-dependent cells.
              FormWhite solid
              CAS number52665-69-7
              RTECSDM4676000
              Chemical formulaC₂₉H₃₇N₃O₆
              Structure formulaStructure formula
              Purity≥98% by TLC
              SolubilityDMSO or Methanol. For use in aqueous systems, preparation of a 100 mM stock in DMSO is recommended. Microliter amounts of this solution can then be added to H₂O with rapid mixing (e.g. 10 µl into 5 ml of H₂O). In aqueous systems, the ionophore aggregates over time.
              Storage Protect from light
              +2°C to +8°C
              Do Not Freeze Ok to freeze
              Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 2 months at -20°C.
              Toxicity Standard Handling
              Merck USA index14, 1639
              ReferencesCaron-Leslie, L.A., et al. 1994. FASEB J. 8, 639.
              Saunders, M.J., and Hepler, P.K. 1982. Science 217, 943.
              Pressman, B.C. 1976. Annu. Rev. Biochem. 45, 501.
              Pfeiffer, D.R., et al. 1974. Biochemistry 13, 4007.
              Reed, P.W., and Lardy, H.A. 1972. J. Biol. Chem. 247, 6970.

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              Categories

              Life Science Research > Inhibitors and Biochemicals > Biochemicals > Ionophores