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ABS2119 Anti-TTC39B

Anti-TTC39B, Cat. No. ABS2119, is a rabbit polyclonal antibody that detects Tetratricopeptide repeat protein 39B and has been tested for use in Western Blotting.

Anti-TTC39B MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Research Category: Signaling Gene Symbol: TTC39B, C9orf52 UniProt Number: Q5VTQ0
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ABS2119
100 μg  
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      Overview

      Replacement Information

      Key Specifications Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      M, HWBRbPurifiedPolyclonal Antibody
      Description
      Catalogue NumberABS2119
      DescriptionAnti-TTC39B
      Alternate Names
      • Tetratricopeptide repeat protein 39B
      • TPR repeat protein 39B
      Background InformationTetratricopeptide repeat protein 39B (UniProt: also known as TPR repeat protein 39B, TTC39B) is encoded by the TTC39B (also known as C9orf52) gene (Gene ID: 158219) in human. TTC39B protein contains two TPR repeats (aa 393-426 and 626-659). TCC39B protein is the product of a high density lipoprotein (HDL) gene that promotes the ubiquitination and degradation of liver X receptor (LXR). TTC39B null or deficient mice challenged with high fat/cholesterol/bile salt diet exhibit increased LXR protein and target gene expression. TTC39B deficiency is reported to stabilize LXR by reducing its polyubiquitination and proteasomal degradation. Hence, it reduces the incidence of atherosclerosis and steatohepatitis. TTC39B deficient mice display higher levels of HDL and apoplipoprotein A-1 and lower levels of hepatic triglyceride synthesis. However, it does not affect glucose tolerance or hepatic gluconeogenesis. (Ref.: Hsieh, J et al. (2016). Nature 535(7611): 303-307).
      References
      Product Information
      FormatPurified
      PresentationPurified rabbit polyclonal antibody in PBS with 0.05% sodium azide.
      Quality LevelMQ100
      Applications
      ApplicationAnti-TTC39B, Cat. No. ABS2119, is a rabbit polyclonal antibody that detects Tetratricopeptide repeat protein 39B and has been tested for use in Western Blotting.
      Key Applications
      • Western Blotting
      Application NotesWestern Blotting Analysis: A representative lot detected TTC39B in cultured primary mouse hepatocytes transfected with T39 (Hsieh, J., et. al. (2016). Nature. 535(7611):303-7).
      Biological Information
      ImmunogenKLH-conjugated linear peptide corresponding to 20 amino acids from the C-terminal half of human Tetratricopeptide repeat protein (TTC39B).
      Epitopeunknown
      ConcentrationPlease refer to lot specific datasheet.
      HostRabbit
      SpecificityThis rabbit polyclonal antibody detects TTC39B in human and murine cells. It targets an epitope with in 20 amino acids from the C-terminal half.
      IsotypeIgG
      Species Reactivity
      • Mouse
      • Human
      Species Reactivity NoteHuman, Mouse. Predicted to react with Rat based on 100% sequence homology.
      Antibody TypePolyclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • TTC39B
      • C9orf52
      Purification MethodAffinity Purified
      UniProt Number
      Molecular Weight~90 kDa observed; 76.96 kDa calculated. Uncharacterized bands may be observed in some lysate(s).
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Western Blotting in HEK293T cells transfected with TTC39B.

      Western Blotting Analysis: 1 µg/mL of this antibody detected TTC39B in 10 µg of TTC39B transfected HEK293T cell lysate.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Packaging Information
      Material Size100 μg
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalog Number GTIN
      ABS2119 04054839251030