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MABT1491-100UG Anti-ZNF175 (OTK18) Antibody, clone 211−3.1−1

Anti-OTK18(ZNF175) clone 211 3.1 1, Cat. No. MABT1491, is a mouse monoclonal antibody that detects Zinc finger protein 175 (OTK18) and has been tested for use in ELISA and Immunocytochemistry.

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MABT1491-100UG
100 μg  
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      Overview

      Replacement Information
      Description
      Catalogue NumberMABT1491-100UG
      DescriptionAnti-ZNF175 (OTK18) Antibody, clone 211−3.1−1
      Alternate Names
      • Zinc finger protein OTK18
      Background InformationZinc finger protein 175 (UniProt: Q9Y473; also known as Zinc finger protein OTK18) is encoded by the ZNF175 gene (Gene ID: 7728) in human. ZNF175 is zinc finger protein that contains 13 C2H2 type zinc fingers and is shown to be ubiquitous in its expression. ZNF175 displays antiviral activity and it is produced during HIV-1 infection of mononuclear phagocytes in human and interferes with HIV-1 replication by suppressing Tat-induced viral LTR promoter activity. It down-regulates the expression of several chemokine receptors and plays a role in the interaction of viral and host cell factors leading to HIV-1 associated dementia and HIV-1 encephalitis. ZNF175 contains a Krüppel associated box (KBAB; aa 26-89) domain that is responsible for its repressive activity. Plasma levels of ZNF175 are reported to correlate with CD8 count and HIV status. (Ref.: Buescher, J., et al. (2008). J Neuroimmune Pharmacol. 3(4); 230-235).
      References
      Product Information
      FormatPurified
      PresentationPurified mouse monoclonal antibody IgG1 in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
      Applications
      ApplicationAnti-OTK18(ZNF175) clone 211 3.1 1, Cat. No. MABT1491, is a mouse monoclonal antibody that detects Zinc finger protein 175 (OTK18) and has been tested for use in ELISA and Immunocytochemistry.
      Key Applications
      • Immunocytochemistry
      • ELISA
      Application NotesELISA Analysis: A representative lot detected OTK18(ZNF175) in ELISA applications (Buescher, J.L., et. al. (2008). J Neuroimmune Pharmacol. 3(4):230-5).
      Biological Information
      ImmunogenHis-tagged recombinant fragment corresponding to the first 178 amino acids from the N-terminal region of human Zinc finger protein 175.
      EpitopeN-terminus
      Clone211−3.1−1
      ConcentrationPlease refer to lot specific datasheet.
      HostMouse
      SpecificityClone 211 3.1 1 specifically detects human Zinc finger protein 175. It targets an epitope with in the first 178 amino acids from the N-terminal region.
      IsotypeIgG1κ
      Species Reactivity
      • Human
      Species Reactivity NoteHuman.
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • ZNF175
      Purification MethodProtein G purified
      UniProt Number
      Molecular Weight81.61 kDa calculated.
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Immunocytochemistry in HeLa cells.

      Immunocytochemistry Analysis: A 1:50 dilution of this antibody detected OTK18(ZNF175) in HeLa cells.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Packaging Information
      Material Size100 μg
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalog Number GTIN
      MABT1491-100UG 04054839577154

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