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344036 cFMS Receptor Tyrosine Kinase Inhibitor - CAS 870483-87-7 - Calbiochem

Overview

Key Specifications Table

CAS #Empirical Formula
870483-87-7C₂₀H₂₂N₄O₃

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344036-1MG
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      Description
      OverviewA cell-permeable diaminopyrimidine compound that acts as a potent, selective, and ATP-competitive inhibitor of cFMS kinase activity (IC50 = 30 nM) with minimal inhibition towards a panel of 26 other kinases (IC50 >5 µM). Shown to selectively inhibit cFMS-mediated cellular functions in vitro as well as CSF-1-dependent tumor growth in vivo. A 10 mM (1 mg/273 µl) solution of cFMS Receptor Tyrosine Kinase Inhibitor (Cat. No. 344041) in DMSO is also available.
      Catalogue Number344036
      Brand Family Calbiochem®
      Synonyms5-(3-Methoxy-4-((4-methoxybenzyl)oxy)benzyl)-pyrimidine-2,4-diamine, CSF-1 Receptor Inhibitor, GW2580
      References
      ReferencesConway, J.G., et al. 2005. Proc. Natl. Acad. Sci. USA 102, 16078.
      Product Information
      CAS number870483-87-7
      ATP CompetitiveY
      FormOff-white solid
      Hill FormulaC₂₀H₂₂N₄O₃
      Chemical formulaC₂₀H₂₂N₄O₃
      ReversibleN
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Biological Information
      Primary TargetCFMS
      Primary Target IC<sub>50</sub>30 nM against cFMS kinase activity
      Purity≥97% by HPLC
      Physicochemical Information
      Cell permeableY
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Global Trade Item Number
      Catalog Number GTIN
      344036-1MG 04055977195149