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204882 Complement C2, Human

Complement C2, Human, is a native, single chain glycoprotein present. C2 is cleaved by the activated C1s into C2a, the 63 kDa C-terminal fragment, and C2b, the 30 kDa N-terminal fragment.

Complement C2, Human MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
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204882
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Overview

Replacement Information

Pricing & Availability

Catalog Number AvailabilityPackaging Qty/Pack Price Quantity
204882-50UG
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      		 Plastic ampoule 50 μg
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      Description
      OverviewNative, human C2 complement component. Single chain glycoprotein present in normal human serum at concentration of 20 µg/ml. Classical pathway activation results in assembly of the C1,C4b complex on target surfaces. Subsequent to binding of the C4b component to this complex, C2 is cleaved by the activated C1s subcomponent of C1 into C2a, the 63 kDa C-terminal fragment, and C2b, the 30 kDa N-terminal fragment. The smaller C2b fragment is released while the larger C2a fragment remains associated with the C1,C4b complex to form the C4b,C2a classical pathway C3 convertase enzyme. C2 concentration is based on functional activity measurements relative to a normal human serum standard pool.
      Catalogue Number204882
      Brand Family Calbiochem®
      References
      ReferencesAttwood, J.T., et al. 2001. Acta Paediatr. 90, 99.
      Product Information
      Activity≥4 × 10⁵ C₂H₅0 units/mg; ≥70% of the C2 activity in normal human serum on a mg/mg basis
      FormLiquid
      FormulationIn PBS, pH 6.0.
      Quality LevelMQ100
      Applications
      Biological Information
      Purity≥90% by SDS-PAGE
      SourcePrepared from plasma that has been shown by certified tests to be negative for HBsAg and for antibodies to HIV and HCV.
      Concentration Label Please refer to vial label for lot-specific concentration
      Physicochemical Information
      ContaminantsC1, C3, C4, C5, IgG, IgA, IgM, albumin, Factor B, or hemopexin:
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Dry Ice Only
      Toxicity Standard Handling
      Storage ≤ -70°C
      Avoid freeze/thaw Avoid freeze/thaw
      Do not freeze Ok to freeze
      Special InstructionsFollowing initial thaw, aliquot and freeze (-70°C).
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalog Number GTIN
      204882-50UG 04055977219760

      Documentation

      Complement C2, Human SDS

      Title

      Safety Data Sheet (SDS) 

      Complement C2, Human Certificates of Analysis

      TitleLot Number
      204882

      References

      Reference overview
      Attwood, J.T., et al. 2001. Acta Paediatr. 90, 99.

      Citations

      Title
    • Inal J.M., and Schifferli, J.A., (2002) Journal of Immunology 168, 5213.
      		•
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision27-May-2008 RFH
      DescriptionNative, human C2 complement component. Single chain glycoprotein present in normal human serum at concentration of 20 µg/ml. Classical pathway activation results in assembly of the C1,C4b complex on target surfaces. Subsequent to binding of the C4b component to this complex, C2 is cleaved by the activated C1s subcomponent of C1 into C2a, the 63 kDa C-terminal fragment, and C2b, the 30 kDa N-terminal fragment. The smaller C2b fragment is released while the larger C2a fragment remains associated with the C1,C4b complex to form the C4b,C2a classical pathway C3 convertase enzyme. C2 concentration is based on functional activity measurements relative to a normal human serum standard pool.
      FormLiquid
      FormulationIn PBS, pH 6.0.
      Concentration Label Please refer to vial label for lot-specific concentration
      SourcePrepared from plasma that has been shown by certified tests to be negative for HBsAg and for antibodies to HIV and HCV.
      Purity≥90% by SDS-PAGE
      ContaminantsC1, C3, C4, C5, IgG, IgA, IgM, albumin, Factor B, or hemopexin:
      Activity≥4 × 10⁵ C₂H₅0 units/mg; ≥70% of the C2 activity in normal human serum on a mg/mg basis
      Storage Avoid freeze/thaw
      ≤ -70°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing initial thaw, aliquot and freeze (-70°C).
      Toxicity Standard Handling
      ReferencesAttwood, J.T., et al. 2001. Acta Paediatr. 90, 99.
      Citation
    • Inal J.M., and Schifferli, J.A., (2002) Journal of Immunology 168, 5213.
      		•