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444235 MMP-13 Substrate, Fluorogenic - Calbiochem

A quenched fluorescence substrate for MMP-13 (collagenase-3; kcat/Km = 1.09 x 10⁶ M⁻¹s⁻¹).

MMP-13 Substrate, Fluorogenic - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: Collagenase-3 Substrate, Fluorogenic

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444235
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Overview

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444235-1MG
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      Description
      OverviewA quenched fluorescence substrate for MMP-13 (collagenase-3; kcat/Km = 1.09 x 106 M-1s-1). Less efficient as a substrate for MMP-1 (fibroblast collagenase) or MMP-8 (neutrophil collagenase).
      Catalogue Number444235
      Brand Family Calbiochem®
      SynonymsCollagenase-3 Substrate, Fluorogenic
      References
      ReferencesKnauper, V., et al. 1996. J. Biol. Chem. 271, 1544.
      Product Information
      ATP CompetitiveN
      FormYellow lyophilized solid
      FormulationSupplied as a trifluoroacetate salt.
      Hill FormulaC₅₁H₆₅N₁₃O₁₅
      Chemical formulaC₅₁H₆₅N₁₃O₁₅
      ReversibleN
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetA quenched fluorescence substrate for MMP-13 (collagenase-3)
      Primary Target IC<sub>50</sub>kcat/Km = 1.09 x 106 M⁻¹ sec⁻¹ for MMP-13 (collagenase-3)
      Purity≥98% by HPLC
      Physicochemical Information
      Cell permeableN
      Emission max.
      Excitation max.
      Peptide SequenceMCA-Pro-Cha-Gly-Nva-His-Ala-Dpa-NH₂ [Cha = L-cyclohexylalanine; Dpa = 3-(2,4-dinitrophenyl)-L-2,3-diaminopropionyl; Nva = L-norvaline]
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage -20°C
      Protect from Light Protect from light
      Protect from Moisture Protect from moisture
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalog Number GTIN
      444235-1MG 04055977186420

      Documentation

      MMP-13 Substrate, Fluorogenic - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      MMP-13 Substrate, Fluorogenic - Calbiochem Certificates of Analysis

      TitleLot Number
      444235

      References

      Reference overview
      Knauper, V., et al. 1996. J. Biol. Chem. 271, 1544.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision06-August-2008 RFH
      SynonymsCollagenase-3 Substrate, Fluorogenic
      DescriptionA quenched fluorescence substrate for MMP-13 (collagenase-3; kcat/Km = 1.09 x 106 M-1s-1; excitation maximum: ~325 nm; emission maximum: ~393 nm). Less efficient as a substrate for MMP-1 (fibroblast collagenase) or MMP-8 (neutrophil collagenase).
      FormYellow lyophilized solid
      FormulationSupplied as a trifluoroacetate salt.
      Chemical formulaC₅₁H₆₅N₁₃O₁₅
      Peptide SequenceMCA-Pro-Cha-Gly-Nva-His-Ala-Dpa-NH₂ [Cha = L-cyclohexylalanine; Dpa = 3-(2,4-dinitrophenyl)-L-2,3-diaminopropionyl; Nva = L-norvaline]
      Purity≥98% by HPLC
      SolubilityDMSO (5 mg/ml)
      Storage Protect from moisture
      Protect from light
      -20°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Standard Handling
      ReferencesKnauper, V., et al. 1996. J. Biol. Chem. 271, 1544.