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14-694M NEK3 Protein, active, 250 µg

Active, N-terminal 6His-tagged, recombinant, full length, human NEK3. For use in Kinase Assays.

14-694M
250 µg  Also available in 10 μg size (cat#14-694) and in bulk (cat# 14-694-K).
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      Overview

      Replacement Information
      Description
      Catalogue Number14-694M
      Brand Family Upstate
      Trade Name
      • Upstate
      DescriptionNEK3 Protein, active, 250 µg
      OverviewN-terminal 6His-tagged, recombinant, full length, human NEK3.
      References
      Product Information
      Quality LevelMQ300
      Applications
      ApplicationActive, N-terminal 6His-tagged, recombinant, full length, human NEK3. For use in Kinase Assays.
      Key Applications
      • Kinase Assay
      Biological Information
      SourceHuman NEK3, expressed by baculovirus in Sf21 cells.
      Specific ActivityFor Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme.
      Entrez Gene Number
      Entrez Gene SummaryIn Aspergillus nidulans, lack of the serine/threonine kinase NimA (never in mitosis A) results in cell cycle arrest in G2, while overexpression causes the premature onset of mitotic events. The protein encoded by this gene is similar in sequence to the Aspergillus nidulans protein and may therefore play a role in mitotic regulation. However, the encoded protein differs from other NimA family members in that it is not cell cycle regulated and is found primarily in the cytoplasm. Three transcript variants have been found for this gene, but the full-length nature of only two of them has been characterized.
      Gene Symbol
      • NEK3
      • HSPK36
      • MGC29949
      Protein TargetNEK3
      Purification MethodNi2+/NTA-agarose
      Target Sub-FamilyMisc
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: P51956 # Kinase that may play a role in mitotic regulation.
      COFACTOR: Magnesium.
      SIZE: 506 amino acids; 57705 Da
      SIMILARITY: SwissProt: P51956 ## Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. NIMA subfamily. & Contains 1 protein kinase domain.
      Molecular Weight62.2kDa
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality Assuranceroutinely evaluated by phosphorylation of MBP (13-104).
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage Conditions6 months at -70°C from date of shipment
      Packaging Information
      Material Size250 µg
      Material PackageAlso available in 10 μg size (cat#14-694) and in bulk (cat# 14-694-K).
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalog Number GTIN
      14-694M 04053252582714

      Documentation

      Related Products & Applications

      Alternative Packsize

      Catalog Number Description  
      14-694 NEK3 Protein, active, 10 µg Show Pricing & Availability

      Product Families

      Kinase & Phosphatase Products

      Millipore offers a large portfolio of Kinases, Phophatases, Substrates, Inhibitors, Kits, reagents & tools for Signaling research. See below for a list of these products, in multiple pack sizes.
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      Categories

      Life Science Research > Proteins and Enzymes > Purified Kinases
      Life Science Research > Drug Discovery and Development > Kinase & Phosphatase Screening > Purified Kinases