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14-786M PI3 Kinase (p110α/p65α) Murine, 250 µg

Complex of N-terminal 6His-tagged, recombinant, full-length mouse p110α & untagged, recombinant, full length mouse p65α. For use in Kinase Assays.

PI3 Kinase (p110α/p65α) Murine, 250 µg MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
14-786M
250 µg  Also available in 10 μg size (cat#14-786) and in bulk (cat# 14-786-K).
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      Overview

      Replacement Information
      Description
      Catalogue Number14-786M
      Brand Family Upstate
      Trade Name
      • Upstate
      DescriptionPI3 Kinase (p110α/p65α) Murine, 250 µg
      OverviewComplex of N-terminal 6His-tagged, recombinant, full-length mouse p110α and untagged, recombinant, full length mouse p65α.
      Background Informationp65α is an oncogenic mutant form of p85α(residues 1-571) which leads to increased PI3K activity.
      References
      Product Information
      Quality LevelMQ300
      Applications
      ApplicationComplex of N-terminal 6His-tagged, recombinant, full-length mouse p110α & untagged, recombinant, full length mouse p65α. For use in Kinase Assays.
      Key Applications
      • Kinase Assay
      Biological Information
      SourceCoexpressed by baculovirus in Sf21 insect cells
      Specific ActivityFor Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme.
      Entrez Gene Number
      Entrez Gene SummaryPhosphatidylinositol 3-kinase is composed of an 85 kDa regulatory subunit and a 110 kDa catalytic subunit. The protein encoded by this gene represents the catalytic subunit, which uses ATP to phosphorylate PtdIns, PtdIns4P and PtdIns(4,5)P2. This gene has been found to be oncogenic and has been implicated in cervical cancers.
      Gene Symbol
      • PIK3CA
      • PI3K
      • MGC142161
      • p110-alpha
      • MGC142163
      Protein TargetPI3Kα/p65α
      Purification MethodNi2+/NTA-agarose
      Target Sub-FamilyPI3K/PI4K
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: P42336 # Phosphorylates PtdIns, PtdIns4P and PtdIns(4,5)P2 with a preference for PtdIns(4,5)P2.
      SIZE: 1068 amino acids; 124284 Da
      SUBUNIT: Heterodimer of a p110 (catalytic) and a p85 (regulatory) subunit. Binds to IRS1 in nuclear extracts. Interacts with RUFY3 (By similarity).
      DISEASE: SwissProt: P42336 # Defects in PIK3CA are associated with colorectal cancer (CRC) [MIM:114500]. & Defects in PIK3CA are associated with breast cancer [MIM:114480]. & Defects in PIK3CA are associated with epithelial ovarian cancer (EOC) [MIM:604370].
      SIMILARITY: SwissProt: P42336 ## Belongs to the PI3/PI4-kinase family. & Contains 1 C2 domain. & Contains 1 PI3K/PI4K domain.
      Molecular Weightp110α MW = 129kDa, p65α MW = 65.9kDa
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStore at -70°C from date of shipment. For maximum recovery of product, centrifuge original vial prior to removing the cap
      Packaging Information
      Material Size250 µg
      Material PackageAlso available in 10 μg size (cat#14-786) and in bulk (cat# 14-786-K).
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalog Number GTIN
      14-786M 04053252333132

      Related Products & Applications

      Alternative Packsize

      Catalog Number Description  
      14-786 PI3 Kinase (p110α/p65α) Murine, 10 µg Show Pricing & Availability

      Product Families

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      Millipore offers a large portfolio of Kinases, Phophatases, Substrates, Inhibitors, Kits, reagents & tools for Signaling research. See below for a list of these products, in multiple pack sizes.
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      Categories

      Life Science Research > Proteins and Enzymes > Purified Kinases
      Life Science Research > Drug Discovery and Development > Kinase & Phosphatase Screening > Purified Kinases