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MAB384-1ML Anti-Myelin Basic Protein Antibody, a.a. 67-74, clone 26

Anti-Myelin Basic Protein Antibody, a.a. 67-74, clone 26 detects level of Myelin Basic Protein & has been published & validated for use in WB, IH.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Research Category: Neuroscience Research Sub-Category: Neuronal & Glial Markers, Neurochemistry & Neurotrophins Gene Symbol: MBP, MGC99675, Golli-mbp UniProt Number: P02686
MAB384-1ML
1 mL  
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      Overview

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      Key Specifications Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      HWB, IHCMCulture SupernatantMonoclonal Antibody
      Description
      Catalogue NumberMAB384-1ML
      ReplacesMAB384
      Brand Family Chemicon®
      Trade Name
      • Chemicon
      DescriptionAnti-Myelin Basic Protein Antibody, a.a. 67-74, clone 26
      Alternate Names
      • MBP
      References
      Product Information
      FormatCulture Supernatant
      PresentationTissue culture supernatant. Liquid containing 0.09% sodium azide.
      Quality LevelMQ100
      Applications
      ApplicationAnti-Myelin Basic Protein Antibody, a.a. 67-74, clone 26 detects level of Myelin Basic Protein & has been published & validated for use in WB, IH.
      Key Applications
      • Western Blotting
      • Immunohistochemistry
      Application NotesWestern blotting

      Immunohistochemistry - on frozen sections.

      Optimal working dilutions must be determined by end user.
      Biological Information
      ImmunogenHuman myelin basic protein.
      Epitopea.a. 67-74
      Clone26
      HostMouse
      SpecificityReacts with an epitope of myelin basic protein between aa 67-74.

      Amino acid sequence YGSLPQ. Reacts with MBP from most species.
      IsotypeIgG1
      Species Reactivity
      • Human
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Entrez Gene SummaryThe protein encoded by the classic MBP gene is a major constituent of the myelin sheath of oligodendrocytes and Schwann cells in the nervous system. However, MBP-related transcripts are also present in the bone marrow and the immune system. These mRNAs arise from the long MBP gene (otherwise called "Golli-MBP") that contains 3 additional exons located upstream of the classic MBP exons. Alternative splicing from the Golli and the MBP transcription start sites gives rise to 2 sets of MBP-related transcripts and gene products. The Golli mRNAs contain 3 exons unique to Golli-MBP, spliced in-frame to 1 or more MBP exons. They encode hybrid proteins that have N-terminal Golli aa sequence linked to MBP aa sequence. The second family of transcripts contain only MBP exons and produce the well characterized myelin basic proteins. This complex gene structure is conserved among species suggesting that the MBP transcription unit is an integral part of the Golli transcription unit and that this arrangement is important for the function and/or regulation of these genes.
      Gene Symbol
      • MBP
      • MGC99675
      • Golli-mbp
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: P02686 # The classic group of MBP isoforms (isoform 4-isoform 14) are with PLP the most abundant protein components of the myelin membrane in the CNS. They have a role in both its formation and stabilization. The smaller isoforms might have an important role in remyelination of denuded axons in multiple sclerosis. The non- classic group of MBP isoforms (isoform 1-isoform 3/Golli-MBPs) may preferentially have a role in the early developing brain long before myelination, maybe as components of transcriptional complexes, and may also be involved in signaling pathways in T- cells and neural cells. Differential splicing events combined to optional post-translational modifications give a wide spectrum of isomers, each of them having maybe a specialized function. Induces T-cell proliferation.
      SIZE: 304 amino acids; 33117 Da
      SUBUNIT: Homodimer; isoform 3 exists as a homodimer.
      SUBCELLULAR LOCATION: Myelin membrane; Peripheral membrane protein; Cytoplasmic side. Note=Cytoplasmic side of myelin.
      TISSUE SPECIFICITY: MBP isoforms are found in both the central and the peripheral nervous system, whereas Golli-MBP isoforms are expressed in fetal thymus, spleen and spinal cord, as well as in cell lines derived from the immune system.DEVELOPMENTAL STAGE: Expression turns on abruptly in fetus of 14 to 16 weeks. Even smaller isoforms seem to be produced during embryogenesis, some of these persisting in the adult. Expression of isoform MBP2 is more evident at 16 weeks and its relative proportion declined thereafter.
      PTM: Several charge isomers of MBP; C1 (the most cationic, least modified, and most abundant form), C2, C3, C4, C5, C6, C7, C8-A and C8-B (the least cationic form); are produced as a result of optional PTM, such as phosphorylation, deamidation of glutamine or asparagine, arginine citrullination and methylation. C8-A and C8-B contain each two mass isoforms termed C8-A(H), C8-A(L), C8-B(H) and C8-B(L), (H) standing for higher and (L) for lower molecular weight. C3, C4 and C5 are phosphorylated. The ratio of methylated arginine residues decreases in aging, making the protein more cationic. & The N-terminal alanine is acetylated (isoform 3, isoform 4, isoform 5 and isoform 6). & Arg-241 was found to be 6% monomethylated and 60% symmetrically dimethylated.
      DISEASE: SwissProt: P02686 # The reduction in the surface charge of citrullinated and/or methylated MBP could result in a weakened attachment to the myelin membrane. This mechanism could be operative in demyelinating diseases such as chronical multiple sclerosis (MS), and fulminating MS (Marburg disease).
      SIMILARITY: SwissProt: P02686 ## Belongs to the myelin basic protein family.
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsMaintain at -20° in undiluted aliquots for up to 12 months after date of receipt. Avoid repeated freeze-thaw cycles.
      Packaging Information
      Material Size1 mL
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalog Number GTIN
      MAB384-1ML 04053252613050

      Documentation

      Anti-Myelin Basic Protein Antibody, a.a. 67-74, clone 26 Certificates of Analysis

      TitleLot Number
      MOUSE ANTI-MYELIN BASIC PROTEIN (MBP) (67-74) 2465133
      MOUSE ANTI-MYELIN BASIC PROTEIN (MBP) (67-74) MONOCLONAL ANTIBODY - 2446675 2446675
      MOUSE ANTI-MYELIN BASIC PROTEIN (MBP) (67-74) - 3305140 3305140
      MOUSE ANTI-MYELIN BASIC PROTEIN (MBP) (67-74) - 3501834 3501834
      MOUSE ANTI-MYELIN BASIC PROTEIN (MBP) (67-74) - 3509173 3509173
      MOUSE ANTI-MYELIN BASIC PROTEIN (MBP) (67-74) - 3729450 3729450
      MOUSE ANTI-MYELIN BASIC PROTEIN (MBP) (67-74) - 3862676 3862676
      MOUSE ANTI-MYELIN BASIC PROTEIN (MBP) (67-74) -2806946 2806946
      MOUSE ANTI-MYELIN BASIC PROTEIN (MBP) (67-74) MONOCLONAL ANTIBODY 3008456
      MOUSE ANTI-MYELIN BASIC PROTEIN (MBP) (67-74) MONOCLONAL ANTIBODY 2933821
      Show more

      References

      Reference overviewPub Med ID
      Region-specific immunoassays for human myelin basic protein.
      Groome, N P, et al.
      J. Neuroimmunol., 12: 253-64 (1986)  1986

      Show Abstract       		2428830 2428830

      Data Sheet

      Title
      MOUSE ANTI-MYELIN BASIC PROTEIN (MBP) (67-74) MONOCLONAL ANTIBODY

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      Product Families

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      Millipore’s MBP antibodies demonstrate specificity against Myelin basic protein (MBP). See below for related products for MBP, based on the expertise of Upstate & Chemicon.
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      Glial Cell Markers

      Glial cells, sometimes called neuroglia are non-neuronal cells that maintain homeostasis, form myelin, and provide support and protection for neurons in the brain and peripheral nervous system.
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      Categories

      Life Science Research > Antibodies and Assays > Primary Antibodies