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ABC830 Anti-SEC62 Antibody

Anti-SEC62 Antibody detects level of SEC62 & has been published & validated for use in SEC62.

Anti-SEC62 Antibody MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Research Category: Apoptosis & Cancer Research Sub-Category: Apoptosis - Additional Gene Symbol: SEC62, TLOC1 UniProt Number: Q99442
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ABC830
100 µg  
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      Overview

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      Key Specifications Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      R, MWB, IHCRbAffinity PurifiedPolyclonal Antibody
      Description
      Catalogue NumberABC830
      DescriptionAnti-SEC62 Antibody
      Alternate Names
      • Translocation protein SEC62
      • Translocation protein 1
      • TP-1
      • hTP-1
      Background InformationTranslocation protein SEC62, also known as Translocation protein 1 (TP-1) or (hTP-1), and encoded by the gene name SEC62, is an integral membrane protein located in the rough endoplasmic reticulum (ER) and is part of the SEC61-SEC62-SEC63 complex. This complex is the central component of the protein translocation apparatus of the ER membrane. It is speculated that SEC61-SEC62-SEC63 may perform post-translational protein translocation into the ER and might also perform the backward transport of ER proteins that are subject to the ubiquitin-proteasome-dependent degradation pathway. Silencing of this gene with RNAi dramatically reduced the migration and invasive potential of numerous tumor cell lines, suggesting that it may be an attractive target for therapy of various tumors.
      References
      Product Information
      FormatAffinity Purified
      PresentationPurified rabbit polyclonal in buffer containing PBS with up to 0.1% sodium azide.
      Quality LevelMQ100
      Applications
      ApplicationAnti-SEC62 Antibody detects level of SEC62 & has been published & validated for use in SEC62.
      Key Applications
      • Western Blotting
      • Immunohistochemistry
      Application NotesImmunohistochemistry Analysis: 5 μg/mL from a representative lot detected SEC62 in mouse brain tissue.
      Biological Information
      ImmunogenKLH-conjugated synthetic peptide corresponding to the C-terminus of human SEC62.
      EpitopeC-terminus
      ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
      HostRabbit
      SpecificityThis antibody is predicted to not cross-react with other SEC proteins.
      Species Reactivity
      • Rat
      • Mouse
      Antibody TypePolyclonal Antibody
      Gene Symbol
      • SEC62
      • TLOC1
      Purification MethodAntigen Affinity Purified
      UniProt Number
      Molecular Weight~31 and ~43 kDa observed. Uncharacterized bands may be observed in some lysate(s).
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Western Blotting in rat brain tissue lysate.

      Western Blotting Analysis: 0.5 μg/mL of this antibody detected SEC62 in rat brain tissue lysate.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Packaging Information
      Material Size100 µg
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalog Number GTIN
      ABC830 04053252943898