203890 Sigma-AldrichCRAC Channel Inhibitor, BTP2 - CAS 223499-30-7 - Calbiochem
CRAC Channel Inhibitor, BTP2, CAS 223499-30-7, is a cell-permeable, potent blocker of Stim1 and Orai1-coupled Ca2+ release-activated Ca2+ channel-mediated SOCE in RBL-2H3 cells (IC50 = 590 nM).
More>> CRAC Channel Inhibitor, BTP2, CAS 223499-30-7, is a cell-permeable, potent blocker of Stim1 and Orai1-coupled Ca2+ release-activated Ca2+ channel-mediated SOCE in RBL-2H3 cells (IC50 = 590 nM). Less<<MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Synonyms: [N-{4-[3,5-bis(Trifluoromethyl)-1H-pyrazol-1-yl]phenyl}-4-methyl-1,2,3-thiadiazole-5-carboxamide], Pyr2, TPRC3 Channel Inhibitor II
Recommended Products
Overview
| Replacement Information |
|---|
Key Specifications Table
| CAS # | Empirical Formula |
|---|---|
| 223499-30-7 | C₁₅H₉F₆N₅OS |
Pricing & Availability
| Catalog Number | Availability | Packaging | Qty/Pack | Price | Quantity | |
|---|---|---|---|---|---|---|
| 203890-5MG |
|
Plastic ampoule | 5 mg |
|
— |
| Description | |
|---|---|
| Overview | A cell-permeable pyrazole that acts as a more potent blocker of Stim1 and Orai1-coupled CRAC (Ca2+ release-activated Ca2+) channel-mediated SOCE (store-operated Ca2+ entry) in RBL-2H3 cells (IC50 = 590 nM by Fura-2; peak current density pA/pF = -1.13 and -7.50, respectively, with or without 3 µM BTP2/Pyr2 by whole cell clamp) than the transient receptor potential cation channel TRPC3-mediated ROCE (receptor-operated Ca2+ entry) inTRPC3-expressing HEK293 cells (IC50 = 4.21 µM by Fura-2; pA/pF = -1.54 and -18.50, respectively, with or without 3 µM BTP2/Pyr2). A great complement to Pyr 3 (Cat. No. 648490), Pyr6, and Pyr10 in Ca2+ signaling studies. |
| Catalogue Number | 203890 |
| Brand Family | Calbiochem® |
| Synonyms | [N-{4-[3,5-bis(Trifluoromethyl)-1H-pyrazol-1-yl]phenyl}-4-methyl-1,2,3-thiadiazole-5-carboxamide], Pyr2, TPRC3 Channel Inhibitor II |
| Product Information | |
|---|---|
| CAS number | 223499-30-7 |
| ATP Competitive | N |
| Form | Solid |
| Hill Formula | C₁₅H₉F₆N₅OS |
| Chemical formula | C₁₅H₉F₆N₅OS |
| Reversible | N |
| Structure formula Image | |
| Quality Level | MQ100 |
| Biological Information | |
|---|---|
| Primary Target | CRAC Channel |
| Primary Target IC<sub>50</sub> | 590 nM by Fura-2 |
| Purity | ≥95% by HPLC |
| Physicochemical Information | |
|---|---|
| Cell permeable | Y |
| Dimensions |
|---|
| Materials Information |
|---|
| Toxicological Information |
|---|
| Safety Information according to GHS |
|---|
| Safety Information |
|---|
| Product Usage Statements |
|---|
| Packaging Information | |
|---|---|
| Packaged under inert gas | Packaged under inert gas |
| Transport Information |
|---|
| Supplemental Information |
|---|
| Specifications |
|---|
| Global Trade Item Number | |
|---|---|
| Catalog Number | GTIN |
| 203890-5MG | 04055977204070 |
Documentation
CRAC Channel Inhibitor, BTP2 - CAS 223499-30-7 - Calbiochem SDS
| Title |
|---|
CRAC Channel Inhibitor, BTP2 - CAS 223499-30-7 - Calbiochem Certificates of Analysis
| Title | Lot Number |
|---|---|
| 203890 |
References
| Reference overview |
|---|
| Schleifier, H., et al. 2012. Br J Pharmacol In Press Yonetoku, Y., et al. 2006. Bioorg. Med. Chem. 14, 5370. Yonetoku, Y., et al. 2006. Bioorg. Med. Chem. 14, 4750. Zitt, C., et al. 2004. J. Biol. Chem. 279, 12927. Trevillyan, J.M., et al. 2001. J. Biol. Chem. 276, 48118. Djuric, S.W., et al. 2000. J. Med. Chem. 43, 2975. |
| Data Sheet | ||||||||||||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.
|