500526 Sigma-AldrichNOX Inhibitor VII, Thr101 - CAS 727664-79-1 - Calbiochem
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Primary Target:
blocks p22phox c-terminal PRD (proline-rich domain) and p47phox bis-SH3 interaction
MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Synonyms: NADPH Oxidase Inhibitor VII, 6-Fluoro-2-o-tolylbenzo[d]isothiazol-3(2H)-one, 6-Fluoro-2-(2-methylphenyl)-1,2-benzothiazol-3(2H)-one
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Overview
| Replacement Information |
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Key Specifications Table
| CAS # | Empirical Formula |
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| 727664-79-1 | C₁₄H₁₀FNOS |
Pricing & Availability
| Catalog Number | Availability | Packaging | Qty/Pack | Price | Quantity | |
|---|---|---|---|---|---|---|
| 5.00526.0001 |
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Glass bottle | 25 mg |
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| Description | |
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| Overview | A cell-permeable, selenium-to-sulfur substituted Ebselen (Cat. No. 324483) derivative that exhibits similar NOX2 inhibitory activity as Ebselen by blocking p22phox c-terminal PRD (proline-rich domain) and p47phox bis-SH3 interaction. Although less potent than Ebselen in cell-free p22phox PRD-p47phox bis-SH3 binding (IC50 = 4 vs. 0.3 µM) and NOX2 activity (IC50 = 4 vs. 0.6 µM) assays, Thr101 is more potent and NOX2-selective than Ebselen in cell-based assays (Thr101 IC50 /Ebselen IC50 = 0.3/0.5, 3/0.15, 8/no inhibition, 8/0.7 µM, respectively, against NOX2, NOX1, NOX4, and NOX5) and exhibits no glutathione peroxidase activity. Please note that the molecular weight for this compound is batch-specific due to variable water content. Please refer to the vial label or the certificate of analysis for the batch-specific molecular weight. The molecular weight provided represents the baseline molecular weight without water. |
| Catalogue Number | 500526 |
| Brand Family | Calbiochem® |
| Synonyms | NADPH Oxidase Inhibitor VII, 6-Fluoro-2-o-tolylbenzo[d]isothiazol-3(2H)-one, 6-Fluoro-2-(2-methylphenyl)-1,2-benzothiazol-3(2H)-one |
| References | |
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| References | Smith, S.M.E., et al. 2012. Chem. Biol. 19, 752. |
| Product Information | |
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| CAS number | 727664-79-1 |
| Form | Light brown powder |
| Hill Formula | C₁₄H₁₀FNOS |
| Chemical formula | C₁₄H₁₀FNOS |
| Structure formula Image | |
| Quality Level | MQ100 |
| Applications |
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| Biological Information | |
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| Primary Target | blocks p22phox c-terminal PRD (proline-rich domain) and p47phox bis-SH3 interaction |
| Purity | ≥98% by HPLC |
| Physicochemical Information | |
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| Cell permeable | Y |
| Dimensions |
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| Materials Information |
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| Toxicological Information |
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| Safety Information according to GHS |
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| Safety Information |
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| Product Usage Statements |
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| Packaging Information | |
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| Packaged under inert gas | Packaged under inert gas |
| Transport Information |
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| Supplemental Information |
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| Specifications |
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| Global Trade Item Number | |
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| Catalog Number | GTIN |
| 5.00526.0001 | 04055977244892 |
Documentation
NOX Inhibitor VII, Thr101 - CAS 727664-79-1 - Calbiochem SDS
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NOX Inhibitor VII, Thr101 - CAS 727664-79-1 - Calbiochem Certificates of Analysis
| Title | Lot Number |
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| 500526 |
References
| Reference overview |
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| Smith, S.M.E., et al. 2012. Chem. Biol. 19, 752. |
Brochure
| Title |
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| Pathways and Biomarkers of Oxidative Stress |
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Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.
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