Millipore Sigma Vibrant Logo

676500 VEGFR2/Flt3/c-Kit Inhibitor - CAS 796967-10-7 - Calbiochem

The VEGFR2/Flt3/c-Kit Inhibitor, also referenced under CAS 796967-10-7, controls the biological activity of VEGFR2/Flt3/c-Kit. This small molecule/inhibitor is primarily used for Activators/Inducers applications.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: N-(4-(3-Amino-1H-indazol-4-yl)phenyl)-Nʹ-(3-methylphenyl)urea, Vascular Endothelial Growth Factor Receptor-2/Flt3/c-Kit Inhibitor, c-Kit Inhibitor I, Flt-3 Inhibitor V, VEGFR Tyrosine Kinase Inhibitor XXV, VEGFR2 Kinase Inhibitor XXII

View Products on Sigmaaldrich.com
676500
View Pricing & Availability

Overview

Replacement Information

Key Specifications Table

CAS #Empirical Formula
796967-10-7C₂₁H₁₉N₅O

Pricing & Availability

Catalog Number AvailabilityPackaging Qty/Pack Price Quantity
676500-5MG
Retrieving availability...
—
Limited Availability Limited Availability
Stocked 
Discontinued
Limited Quantities Available
Available
    Remaining : Will advise
      Remaining : Will advise
      Will advise
      Contact Customer Service
      Contact Customer Service

      		 Plastic ampoule 5 mg
      Retrieving price...
      Price could not be retrieved
      Minimum Quantity is a multiple of
      Maximum Quantity is
      Upon Order Completion More Information
      You Saved ()
       
      —
      Request Pricing
      		 —
      Description
      OverviewA cell-permeable 3-aminoindazolylurea compound that acts as a potent and ATP-competitive inhibitor of VEGFR2/KDR (IC50 = 3 nM) as well as Flt3 and cKit (IC50 = 4 to 20 nM). Shown to block VEGF-induced VEGFR2 phosphorylation in 3T3-murine fibroblasts in vitro (IC50 = 13 nM) and exhibit oral availability (AUC = 6.5 µM•h with an oral dose of 10 mg/kg in CD-1 mice) and in vivo efficacy in a murine estradiol-induced uterine edema model (ED50 = 4 mg/kg p.o. in balb/c mice).
      Catalogue Number676500
      Brand Family Calbiochem®
      SynonymsN-(4-(3-Amino-1H-indazol-4-yl)phenyl)-Nʹ-(3-methylphenyl)urea, Vascular Endothelial Growth Factor Receptor-2/Flt3/c-Kit Inhibitor, c-Kit Inhibitor I, Flt-3 Inhibitor V, VEGFR Tyrosine Kinase Inhibitor XXV, VEGFR2 Kinase Inhibitor XXII
      References
      ReferencesDai, Y., et al. 2007. J. Med. Chem. 50, 1584.
      Product Information
      CAS number796967-10-7
      FormOff-white solid
      Hill FormulaC₂₁H₁₉N₅O
      Chemical formulaC₂₁H₁₉N₅O
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Purity≥97% by HPLC
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalog Number GTIN
      676500-5MG 04055977260496

      Documentation

      VEGFR2/Flt3/c-Kit Inhibitor - CAS 796967-10-7 - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      VEGFR2/Flt3/c-Kit Inhibitor - CAS 796967-10-7 - Calbiochem Certificates of Analysis

      TitleLot Number
      676500

      References

      Reference overview
      Dai, Y., et al. 2007. J. Med. Chem. 50, 1584.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision31-May-2011 RFH
      SynonymsN-(4-(3-Amino-1H-indazol-4-yl)phenyl)-Nʹ-(3-methylphenyl)urea, Vascular Endothelial Growth Factor Receptor-2/Flt3/c-Kit Inhibitor, c-Kit Inhibitor I, Flt-3 Inhibitor V, VEGFR Tyrosine Kinase Inhibitor XXV, VEGFR2 Kinase Inhibitor XXII
      DescriptionA cell-permeable 3-aminoindazolylurea compound that acts as a potent and ATP-competitive inhibitor of VEGFR2/KDR (IC50 = 3 nM) as well as Flt3 and cKit (IC50 = 4 to 20 nM). Shown to block VEGF-induced VEGFR2 phosphorylation in 3T3-murine fibroblasts in vitro (IC50 = 13 nM) and exhibit oral availability (AUC = 6.5 µM•h with an oral dose of 10 mg/kg in CD-1 mice) and in vivo efficacy in a murine estradiol-induced uterine edema model (ED50 = 4 mg/kg p.o. in balb/c mice).
      FormOff-white solid
      Intert gas (Yes/No) Packaged under inert gas
      CAS number796967-10-7
      Chemical formulaC₂₁H₁₉N₅O
      Structure formulaStructure formula
      Purity≥97% by HPLC
      SolubilityDMSO (100 mg/ml) or Ethanol (10 mg/ml)
      Storage Protect from light
      +2°C to +8°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Toxicity Standard Handling
      ReferencesDai, Y., et al. 2007. J. Med. Chem. 50, 1584.