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MABF270 Anti-STING Antibody, clone S17G2C4B7

Anti-STING Antibody, clone S17G2C4B7 is an antibody against STING for use in Western Blotting, Immunocytochemistry.

Anti-STING Antibody, clone S17G2C4B7 MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Research Category: Inflammation & Immunology Research Sub-Category: Infectious Diseases - Viral Gene Symbol: TMEM173, ERIS, MITA, MPYS, SAVI, STING UniProt Number: Q86WV6
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MABF270
100 μg  
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      Key Specifications Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      H, MWB, ICCMPurifiedMonoclonal Antibody
      Description
      Catalogue NumberMABF270
      DescriptionAnti-STING Antibody, clone S17G2C4B7
      Alternate Names
      • Stimulator of interferon genes protein
      • Endoplasmic reticulum interferon stimulator
      • ERIS
      • hMITA
      • hSTING
      • Mediator of IRF3 activation
      • Transmembrane protein 173
      Background InformationStimulator of interferon genes protein (UniProt Q86WV6; also known as Endoplasmic reticulum interferon stimulator, ERIS, hMITA, hSTING, Mediator of IRF3 activation, Transmembrane protein 173) is encoded by the TMEM173 (also known as ERIS, MITA, MPYS, SAVI, STING) gene (Gene ID 340061) in human. STING is an adaptor protein activated by cytosolic dsDNA or cyclic dinucleotides and plays a critical role in initiating innate responses to infection by various pathogens, including Herpes simplex virus (HSV). Once activated, STING translocates to the endoplasmic reticulum and activates the TBK1/IRF3 pathway that in turn mediates the upregulation of interferon (IFN) β. In addition, the DNA sensor IFI16 is also known to function as a STING ligand and potentiates STING-dependent sensing of viral infection by presenting cellular viral DNA to STING. STING is a four transmembrane (a.a. 21-41, 47-67, 87-106, 116-136) protein with both its N- and C-terminal ends exposed intracellularly (a.a. 1-20 and 137-379).The C-terminal cytoplasmic tail contains the c-di-GMP-binding domain (CBD; a.a. 153-340) with two c-di-GMP-binding regions (a.a. 162-167 & 238-241).
      References
      Product Information
      FormatPurified
      PresentationPurified mouse monoclonal IgG1κ antibody in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
      Quality LevelMQ100
      Applications
      ApplicationAnti-STING Antibody, clone S17G2C4B7 is an antibody against STING for use in Western Blotting, Immunocytochemistry.
      Key Applications
      • Western Blotting
      • Immunocytochemistry
      Application NotesWestern Blotting Analysis: A 1:200 dilution from a representative lot detected the expression of exogenously transfected human and murine STING in HEK293T cells, as well as the endogenous STING in telomerase-immortalized human foreskin fibroblasts hTERT-BJ1 (Courtesy of Dr. Glen N. Barber, University of Miami School of Medicine, FL, U.S.A.).
      Immunocytochemistry Analysis: A 1:50 dilution from a representative lot detected the expression of exogenously transfected human and murine STING in HEK293T cells, as well as the endogenous STING in telomerase-immortalized human foreskin fibroblasts hTERT-BJ1 (Courtesy of Dr. Glen N. Barber, University of Miami School of Medicine, FL, U.S.A.).
      Biological Information
      ImmunogenHis-tagged recombinant human STING C-terminal cytoplasmic domain fragment.
      EpitopeAmino acids 301-315.
      CloneS17G2C4B7
      ConcentrationPlease refer to lot specific datasheet.
      HostMouse
      SpecificityClone S17G2C4B7 recognizes an epitope in the C-terminal cytoplasmic domain of human and murine STING.
      IsotypeIgG1κ
      Species Reactivity
      • Human
      • Mouse
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • TMEM173
      • ERIS
      • MITA
      • MPYS
      • SAVI
      • STING
      Purification MethodProtein G Purified
      UniProt Number
      Molecular Weight~38 kDa observed. 42.19 kDa calculated.
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Western Blotting in HEK293T cell lysate.

      Western Blotting Analysis: 1.0 µg/mL of this antibody detected STING in 50 µg of HEK293T cell lysate.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Packaging Information
      Material Size100 μg
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalog Number GTIN
      MABF270 04055977335149

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      Categories

      Life Science Research > Antibodies and Assays > Primary Antibodies