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487929 Sigma-AldrichInSolution™ Nocodazole - CAS 31430-18-9 - Calbiochem

Inhibitor of mitosis. Has highly specific antimicrotubular activity for mammalian cells in culture.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

SDS
CoA
References
Data Sheet

Synonyms: R17934, Methyl-(5-(2-thienylcarbonyl)-1H-benzimidazol-2-yl)-carbamate, Methyl-5-(thiophene-2-carbonyl)-1H-benzo[d]imidazol-2-ylcarbamate

Primary Target: Microtubules

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Overview

Replacement Information

Key Specifications Table

CAS #	Empirical Formula
31430-18-9	C₁₄H₁₁N₃O₃S

Pricing & Availability

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487929-10MG	Retrieving availability... — Limited Availability Stocked Discontinued Limited Quantities Available Available Login to See Inventory Stocked Limited Availability Stocked Remaining : Will advise Remaining : Will advise Will advise Contact Customer Service Contact Customer Service Contact Customer Service Contact Customer Service	Glass bottle	10 mg	Retrieving price... Price could not be retrieved Minimum Quantity is a multiple of Maximum Quantity is Upon Order Completion More Information You Saved () — Request Pricing Login to See Your Pricing	Check Availability —	Add To Favorites Add To Favorites Added To My Favorites

Description
Overview	Inhibitor of mitosis. Has highly specific antimicrotubular activity for mammalian cells in culture. Promotes tubulin depolymerization. Also acts as a high-affinity ligand for the cancer-related kinases ABL, c-KIT, BRAF, and MEK (K_d < 2 µM). The solid form of this compound (Cat. No. 487928) is also available.
Catalogue Number	487929
Brand Family	Calbiochem®
Synonyms	R17934, Methyl-(5-(2-thienylcarbonyl)-1H-benzimidazol-2-yl)-carbamate, Methyl-5-(thiophene-2-carbonyl)-1H-benzo[d]imidazol-2-ylcarbamate

References
References	Park, H., et al. 2012. Chem. Med. Chem. 7, 53. Bunz, F., et al. 1998. Science 282, 1497. Fleischman, L.F., et al. 1993. Oncogene 8, 771. Pomies, P., and Block, M.R. 1992. Biochem. Biophys. Res. Commun. 189, 1429. Rennison, M.E., et al. 1992. J. Cell Sci. 102, 239. Thyberg, J., and Moskalewski, S. 1992. J. Cell Sci. 103, 1167.

Product Information
CAS number	31430-18-9
Form	Liquid
Formulation	A 50 mM (10 mg/664 µL) solution of Nocodazole (Cat. No. 487928) in DMSO.
Hill Formula	C₁₄H₁₁N₃O₃S
Hygroscopic	Hygroscopic
Reversible	Y
Structure formula Image
Quality Level	MQ100

Applications

Biological Information
Primary Target	Microtubules
Secondary target	Certain kinases
Purity	≥97% by HPLC

Physicochemical Information
Cell permeable	Y

Dimensions

Materials Information

Toxicological Information

Safety Information according to GHS

Safety Information
R Phrase	R: 36/38 Irritating to eyes and skin.
S Phrase	S: 26-36-45 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing. In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).

Product Usage Statements

Storage and Shipping Information
Ship Code	Dry Ice Only
Toxicity	Irritant
Storage	≤ -70°C
Protect from Light	Protect from light
Hygroscopic	Hygroscopic
Avoid freeze/thaw	Avoid freeze/thaw
Do not freeze	Ok to freeze
Special Instructions	Following initial thaw, aliquot and freeze (-70°C). Aliquots are stable for up to 1 year at -70°C.

Packaging Information
Packaged under inert gas	Packaged under inert gas

Transport Information

Supplemental Information

Specifications

Global Trade Item Number
Catalog Number	GTIN
487929-10MG	04055977200393

Documentation

InSolution™ Nocodazole - CAS 31430-18-9 - Calbiochem SDS

Title
Safety Data Sheet (SDS)

InSolution™ Nocodazole - CAS 31430-18-9 - Calbiochem Certificates of Analysis

Title	Lot Number
487929	Enter Lot Number

References

Reference overview
Park, H., et al. 2012. Chem. Med. Chem. 7, 53. Bunz, F., et al. 1998. Science 282, 1497. Fleischman, L.F., et al. 1993. Oncogene 8, 771. Pomies, P., and Block, M.R. 1992. Biochem. Biophys. Res. Commun. 189, 1429. Rennison, M.E., et al. 1992. J. Cell Sci. 102, 239. Thyberg, J., and Moskalewski, S. 1992. J. Cell Sci. 103, 1167.

Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision	14-December-2012 JSW
Synonyms	R17934, Methyl-(5-(2-thienylcarbonyl)-1H-benzimidazol-2-yl)-carbamate, Methyl-5-(thiophene-2-carbonyl)-1H-benzo[d]imidazol-2-ylcarbamate
Description	Inhibitor of mitosis. Has highly specific antimicrotubular activity for mammalian cells in culture. Promotes tubulin depolymerization. Also acts as a high-affinity ligand for the cancer-related kinases ABL, c-KIT, BRAF, and MEK (K_d < 2 µM). The solid form of this compound (Cat. No. 487928) is also available.
Form	Liquid
Formulation	A 50 mM (10 mg/664 µL) solution of Nocodazole (Cat. No. 487928) in DMSO.
Intert gas (Yes/No)	Packaged under inert gas
CAS number	31430-18-9
Structure formula
Purity	≥97% by HPLC
Storage	Protect from light Avoid freeze/thaw ≤ -70°C Hygroscopic
Do Not Freeze	Ok to freeze
Special Instructions	Following initial thaw, aliquot and freeze (-70°C). Aliquots are stable for up to 1 year at -70°C.
Toxicity	Irritant
References	Park, H., et al. 2012. Chem. Med. Chem. 7, 53. Bunz, F., et al. 1998. Science 282, 1497. Fleischman, L.F., et al. 1993. Oncogene 8, 771. Pomies, P., and Block, M.R. 1992. Biochem. Biophys. Res. Commun. 189, 1429. Rennison, M.E., et al. 1992. J. Cell Sci. 102, 239. Thyberg, J., and Moskalewski, S. 1992. J. Cell Sci. 103, 1167.

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