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530618 Pin1 Inhibitor, DTM - CAS 725-32-6 - Calbiochem

A cell permeable competitive inhibitor of Pin1 (EC₅₀ = 4.1 µM, Ki = 50 nM).

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: PPIase-Parvulin Inhibitor II

Primary Target: Pin1
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530618
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Overview

Replacement Information

Key Specifications Table

CAS #Empirical Formula
725-32-6C₁₂H₂₀N₂S₃

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      		 Glass bottle 10 mg
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      Description
      OverviewA cell permeable thiuram monosulfide based compound that acts as a competitive inhibitor of Pin1 (EC50 = 4.1 µM, Ki = 50 nM). Binds to the active site of the PPIase domain of Pin1 hydrophobically and blocks the active pocket. Shown to specifically inhibit peptidyl-prolyl cis/trans isomerase activity in HeLa cells. Inhibits the proliferation of HCT116 cells (EC50 = 10 µM) by arresting cell cycle at the G0 phase. Also shown to reduce the endogenous Runx2 protein levels in the MC3T3-E1 cells. Displays excellent solubility in DMSO (~100 mM).

      Please note that the molecular weight for this compound is batch-specific due to variable water content.
      Catalogue Number530618
      Brand Family Calbiochem®
      SynonymsPPIase-Parvulin Inhibitor II
      References
      ReferencesYoon, W-J., et al. 2013. J. Cell Physiol. 228, 2377.
      Tatara, Y., et al. 2009.Biochem Biophys Res Commun. 384, 394.
      Product Information
      CAS number725-32-6
      FormYellow powder
      Hill FormulaC₁₂H₂₀N₂S₃
      Chemical formulaC₁₂H₂₀N₂S₃
      ReversibleY
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetPin1
      Purity≥98% by HPLC
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalog Number GTIN
      5.30618.0001 04055977260984

      Documentation

      Pin1 Inhibitor, DTM - CAS 725-32-6 - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      References

      Reference overview
      Yoon, W-J., et al. 2013. J. Cell Physiol. 228, 2377.
      Tatara, Y., et al. 2009.Biochem Biophys Res Commun. 384, 394.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision30-May-2014 JSW
      SynonymsPPIase-Parvulin Inhibitor II
      DescriptionA cell permeable thiuram monosulfide based compound that acts as a competitive inhibitor of Pin1 (EC50 = 4.1 µM, Ki = 50 nM). Binds to the active site of the PPIase domain of Pin1 hydrophobically and blocks the active pocket. Shown to specifically inhibit peptidyl-prolyl cis/trans isomerase activity in HeLa cells. Inhibits the proliferation of HCT116 cells (EC50 = 10 µM) by arresting cell cycle at the G0 phase. Also shown to reduce the endogenous Runx2 protein levels in the MC3T3-E1 cells. Displays excellent solubility in DMSO (~100 mM).
      FormYellow powder
      Intert gas (Yes/No) Packaged under inert gas
      CAS number725-32-6
      Chemical formulaC₁₂H₂₀N₂S₃
      Purity≥98% by HPLC
      SolubilityDMSO (50 mg/ml)
      Storage Protect from light
      +2°C to +8°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Standard Handling
      ReferencesYoon, W-J., et al. 2013. J. Cell Physiol. 228, 2377.
      Tatara, Y., et al. 2009.Biochem Biophys Res Commun. 384, 394.